Evaluation of Antiplatelet/Anticoagulant Use and Prognosis in Primary Thrombophilia Patients with COVID-19
Objective: This study is aimed to investigate the relationship between inherited thrombophilia and COVID-19 symptoms and the outcomes of treatment strategies. Materials and Methods: This descriptive and retrospective study included patients who were followed up for thrombophilia in a training and re...
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Sakarya University
2024-12-01
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| Series: | Sakarya Tıp Dergisi |
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| Online Access: | https://dergipark.org.tr/tr/download/article-file/3937402 |
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| author | Cenk Sunu Alper Erkin Ayşe Çelik Yılmaz |
| author_facet | Cenk Sunu Alper Erkin Ayşe Çelik Yılmaz |
| author_sort | Cenk Sunu |
| collection | DOAJ |
| description | Objective: This study is aimed to investigate the relationship between inherited thrombophilia and COVID-19 symptoms and the outcomes of treatment strategies. Materials and Methods: This descriptive and retrospective study included patients who were followed up for thrombophilia in a training and research hospital. Data from 121 patients who had COVID-19 infection and those who met the inclusion criteria were collected through retrospective examination of medical records and telephone interviews using a data collection form developed by the researchers. The data obtained from the study was evaluated using descriptive and comparative statistical methods. Results: Among the patients diagnosed with COVID-19, 11.6% had severe clinical presentations requiring intensive care support. During COVID-19 infection, mostly no drug was preferred for treatment (51.2%), and the most preferred drug was acetylsalicylic acid (ASA) (33.1%). A total of 13 thromboembolic events occurred in 12 patients who were included in the study during and after COVID-19 infection. No thromboembolic events occurred in patients using warfarin or new-generation oral anticoagulants during COVID-19. There was no significant difference in thromboembolism complications among patients who did not use any medication, those who used ASA/clopidogrel, and those who used low molecular weight heparin during COVID-19 infection. The most common gene mutation in the study was plasminogen activator inhibitor-1 (PAI-1) mutation, and there was no statistically significant difference between PAI-1 gene mutation and new thrombotic events (p=0.988). Conclusion: COVID-19 infection was found to cause bilateral lung involvement with diffuse microthrombi in patients with genetic thrombophilia. No new thromboembolic events occurred in patients with thrombophilia using warfarin or new-generation oral anticoagulants. |
| format | Article |
| id | doaj-art-e09e72d158e94fa09511ddfc373470bb |
| institution | DOAJ |
| issn | 2146-409X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Sakarya University |
| record_format | Article |
| series | Sakarya Tıp Dergisi |
| spelling | doaj-art-e09e72d158e94fa09511ddfc373470bb2025-08-20T02:43:46ZengSakarya UniversitySakarya Tıp Dergisi2146-409X2024-12-0114442042710.31832/smj.148571228Evaluation of Antiplatelet/Anticoagulant Use and Prognosis in Primary Thrombophilia Patients with COVID-19Cenk Sunu0https://orcid.org/0000-0002-6513-6211Alper Erkin1https://orcid.org/0000-0001-6144-3727Ayşe Çelik Yılmaz2https://orcid.org/0000-0002-9085-4848SAKARYA ÜNİVERSİTESİSAKARYA ÜNİVERSİTESİDÜZCE ÜNİVERSİTESİObjective: This study is aimed to investigate the relationship between inherited thrombophilia and COVID-19 symptoms and the outcomes of treatment strategies. Materials and Methods: This descriptive and retrospective study included patients who were followed up for thrombophilia in a training and research hospital. Data from 121 patients who had COVID-19 infection and those who met the inclusion criteria were collected through retrospective examination of medical records and telephone interviews using a data collection form developed by the researchers. The data obtained from the study was evaluated using descriptive and comparative statistical methods. Results: Among the patients diagnosed with COVID-19, 11.6% had severe clinical presentations requiring intensive care support. During COVID-19 infection, mostly no drug was preferred for treatment (51.2%), and the most preferred drug was acetylsalicylic acid (ASA) (33.1%). A total of 13 thromboembolic events occurred in 12 patients who were included in the study during and after COVID-19 infection. No thromboembolic events occurred in patients using warfarin or new-generation oral anticoagulants during COVID-19. There was no significant difference in thromboembolism complications among patients who did not use any medication, those who used ASA/clopidogrel, and those who used low molecular weight heparin during COVID-19 infection. The most common gene mutation in the study was plasminogen activator inhibitor-1 (PAI-1) mutation, and there was no statistically significant difference between PAI-1 gene mutation and new thrombotic events (p=0.988). Conclusion: COVID-19 infection was found to cause bilateral lung involvement with diffuse microthrombi in patients with genetic thrombophilia. No new thromboembolic events occurred in patients with thrombophilia using warfarin or new-generation oral anticoagulants.https://dergipark.org.tr/tr/download/article-file/3937402coronavirushereditary thrombophiliacoagulationanticoagulationthrombosiscoronavirushereditary thrombophiliacoagulationanticoagulationthrombosis |
| spellingShingle | Cenk Sunu Alper Erkin Ayşe Çelik Yılmaz Evaluation of Antiplatelet/Anticoagulant Use and Prognosis in Primary Thrombophilia Patients with COVID-19 Sakarya Tıp Dergisi coronavirus hereditary thrombophilia coagulation anticoagulation thrombosis coronavirus hereditary thrombophilia coagulation anticoagulation thrombosis |
| title | Evaluation of Antiplatelet/Anticoagulant Use and Prognosis in Primary Thrombophilia Patients with COVID-19 |
| title_full | Evaluation of Antiplatelet/Anticoagulant Use and Prognosis in Primary Thrombophilia Patients with COVID-19 |
| title_fullStr | Evaluation of Antiplatelet/Anticoagulant Use and Prognosis in Primary Thrombophilia Patients with COVID-19 |
| title_full_unstemmed | Evaluation of Antiplatelet/Anticoagulant Use and Prognosis in Primary Thrombophilia Patients with COVID-19 |
| title_short | Evaluation of Antiplatelet/Anticoagulant Use and Prognosis in Primary Thrombophilia Patients with COVID-19 |
| title_sort | evaluation of antiplatelet anticoagulant use and prognosis in primary thrombophilia patients with covid 19 |
| topic | coronavirus hereditary thrombophilia coagulation anticoagulation thrombosis coronavirus hereditary thrombophilia coagulation anticoagulation thrombosis |
| url | https://dergipark.org.tr/tr/download/article-file/3937402 |
| work_keys_str_mv | AT cenksunu evaluationofantiplateletanticoagulantuseandprognosisinprimarythrombophiliapatientswithcovid19 AT alpererkin evaluationofantiplateletanticoagulantuseandprognosisinprimarythrombophiliapatientswithcovid19 AT aysecelikyılmaz evaluationofantiplateletanticoagulantuseandprognosisinprimarythrombophiliapatientswithcovid19 |