The Relationship Between Age and the Propofol Dose for Anesthesia Induction: A Single-Center Retrospective Study Utilizing Neural Network Model Simulation
Propofol is commonly used for anesthetic induction, but its dose-dependent hypotensive effect remains a concern. Although the required dose for loss of consciousness decreases with age, the optimal induction dose in older individuals is not well established. This retrospective study aimed to constru...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-05-01
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| Series: | Applied Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3417/15/11/6052 |
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| Summary: | Propofol is commonly used for anesthetic induction, but its dose-dependent hypotensive effect remains a concern. Although the required dose for loss of consciousness decreases with age, the optimal induction dose in older individuals is not well established. This retrospective study aimed to construct a neural network model to predict the propofol induction dose and to quantify the relationship between age and the propofol induction dose through model-based simulations. We analyzed data from 405 patients who underwent elective non-cardiac surgery. A multilayer perceptron model (“model N”) was developed to predict the required induction dose based on clinical parameters. Its predictive performance was compared with that of “model P”, a previously published regression equation derived from multivariable analysis, using the RMSE and MAE. Model N showed significantly better accuracy than model P (RMSE: 17.6 vs. 25.8; MAE: 13.0 vs. 16.7; <i>p</i> < 0.001). Simulation utilizing model N revealed that the induction dose of propofol per body weight decreased by approximately 0.1 mg/kg for every 10-year increase in age. These findings suggest that our proposed model may help determine more accurate and safer dosing strategies for elderly patients undergoing general anesthesia. |
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| ISSN: | 2076-3417 |