Maternal–fetal transfer and longitudinal trends of antibodies to Chlamydia trachomatis and Mycoplasma genitalium in early childhood
Abstract Introduction Sexually transmitted infections caused by Chlamydia trachomatis and Mycoplasma genitalium can have significant implications during early childhood. This study aimed to assess maternal antibodies to C. trachomatis and M. genitalium in newborns, their vanishing, and offspring...
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| Format: | Article |
| Language: | English |
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Wiley
2025-07-01
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| Series: | Acta Obstetricia et Gynecologica Scandinavica |
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| Online Access: | https://doi.org/10.1111/aogs.15105 |
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| author | Nea Koskela Julia Butt Birgitta E. Michels Kari Syrjänen Seija Grenman Tim Waterboer Stina Syrjänen Karolina Louvanto |
| author_facet | Nea Koskela Julia Butt Birgitta E. Michels Kari Syrjänen Seija Grenman Tim Waterboer Stina Syrjänen Karolina Louvanto |
| author_sort | Nea Koskela |
| collection | DOAJ |
| description | Abstract Introduction Sexually transmitted infections caused by Chlamydia trachomatis and Mycoplasma genitalium can have significant implications during early childhood. This study aimed to assess maternal antibodies to C. trachomatis and M. genitalium in newborns, their vanishing, and offspring's own seroconversion to these pathogens during the first 3 years of life. Material and Methods Altogether, 309 mother‐neonate pairs originally enrolled in the prospective Finnish Family HPV (FFHPV) cohort study at Turku University Hospital, Finland, were analyzed for serum IgG antibodies to plasmid protein gene 3 (pGP3) for C. trachomatis and M. genitalium protein of adhesion (MgPa N‐term) and recombinant MgPa for M. genitalium using multiplex serology, by serial sampling during a 3‐year follow‐up. Results A significant correlation between maternal and neonate antibodies to both C. trachomatis and M. genitalium was evident up to 2 months after birth and to C. trachomatis also at 6 months (p < 0.001). During the first 3 years of life, three children seroconverted IgG antibodies to C. trachomatis and one to M. genitalium. At the last (36‐month) follow‐up visit, five (2.1%) children were seropositive for C. trachomatis and only one (0.4%) for M. genitalium. Conclusions Both C. trachomatis and M. genitalium IgG antibodies are transferred from the mother to her offspring during pregnancy; similarly, this is shown for nearly all maternal IgG antibodies. Seroconversion for both C. trachomatis and M. genitalium in early childhood was a rare event. Further studies are required to elucidate the significance of C. trachomatis and M. genitalium antibodies acquired in early life. |
| format | Article |
| id | doaj-art-e08f7d030add4cbf97d7edddcfe81ca4 |
| institution | Kabale University |
| issn | 0001-6349 1600-0412 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Acta Obstetricia et Gynecologica Scandinavica |
| spelling | doaj-art-e08f7d030add4cbf97d7edddcfe81ca42025-08-20T03:30:57ZengWileyActa Obstetricia et Gynecologica Scandinavica0001-63491600-04122025-07-0110471366137210.1111/aogs.15105Maternal–fetal transfer and longitudinal trends of antibodies to Chlamydia trachomatis and Mycoplasma genitalium in early childhoodNea Koskela0Julia Butt1Birgitta E. Michels2Kari Syrjänen3Seija Grenman4Tim Waterboer5Stina Syrjänen6Karolina Louvanto7Department of Obstetrics and Gynecology, Faculty of Medicine and Health Technology Tampere University Tampere FinlandGerman Cancer Research Center (DKFZ) Heidelberg GermanyGerman Cancer Research Center (DKFZ) Heidelberg GermanySMW Consultants, Ltd Kaarina FinlandDepartment of Obstetrics and Gynecology, Turku University Hospital University of Turku Turku FinlandGerman Cancer Research Center (DKFZ) Heidelberg GermanyDepartment of Oral Pathology, Institute of Dentistry, Faculty of Medicine University of Turku Turku FinlandDepartment of Obstetrics and Gynecology, Faculty of Medicine and Health Technology Tampere University Tampere FinlandAbstract Introduction Sexually transmitted infections caused by Chlamydia trachomatis and Mycoplasma genitalium can have significant implications during early childhood. This study aimed to assess maternal antibodies to C. trachomatis and M. genitalium in newborns, their vanishing, and offspring's own seroconversion to these pathogens during the first 3 years of life. Material and Methods Altogether, 309 mother‐neonate pairs originally enrolled in the prospective Finnish Family HPV (FFHPV) cohort study at Turku University Hospital, Finland, were analyzed for serum IgG antibodies to plasmid protein gene 3 (pGP3) for C. trachomatis and M. genitalium protein of adhesion (MgPa N‐term) and recombinant MgPa for M. genitalium using multiplex serology, by serial sampling during a 3‐year follow‐up. Results A significant correlation between maternal and neonate antibodies to both C. trachomatis and M. genitalium was evident up to 2 months after birth and to C. trachomatis also at 6 months (p < 0.001). During the first 3 years of life, three children seroconverted IgG antibodies to C. trachomatis and one to M. genitalium. At the last (36‐month) follow‐up visit, five (2.1%) children were seropositive for C. trachomatis and only one (0.4%) for M. genitalium. Conclusions Both C. trachomatis and M. genitalium IgG antibodies are transferred from the mother to her offspring during pregnancy; similarly, this is shown for nearly all maternal IgG antibodies. Seroconversion for both C. trachomatis and M. genitalium in early childhood was a rare event. Further studies are required to elucidate the significance of C. trachomatis and M. genitalium antibodies acquired in early life.https://doi.org/10.1111/aogs.15105C. trachomatisM. genitaliummaternal–fetal transfermothernewbornserology |
| spellingShingle | Nea Koskela Julia Butt Birgitta E. Michels Kari Syrjänen Seija Grenman Tim Waterboer Stina Syrjänen Karolina Louvanto Maternal–fetal transfer and longitudinal trends of antibodies to Chlamydia trachomatis and Mycoplasma genitalium in early childhood Acta Obstetricia et Gynecologica Scandinavica C. trachomatis M. genitalium maternal–fetal transfer mother newborn serology |
| title | Maternal–fetal transfer and longitudinal trends of antibodies to Chlamydia trachomatis and Mycoplasma genitalium in early childhood |
| title_full | Maternal–fetal transfer and longitudinal trends of antibodies to Chlamydia trachomatis and Mycoplasma genitalium in early childhood |
| title_fullStr | Maternal–fetal transfer and longitudinal trends of antibodies to Chlamydia trachomatis and Mycoplasma genitalium in early childhood |
| title_full_unstemmed | Maternal–fetal transfer and longitudinal trends of antibodies to Chlamydia trachomatis and Mycoplasma genitalium in early childhood |
| title_short | Maternal–fetal transfer and longitudinal trends of antibodies to Chlamydia trachomatis and Mycoplasma genitalium in early childhood |
| title_sort | maternal fetal transfer and longitudinal trends of antibodies to chlamydia trachomatis and mycoplasma genitalium in early childhood |
| topic | C. trachomatis M. genitalium maternal–fetal transfer mother newborn serology |
| url | https://doi.org/10.1111/aogs.15105 |
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