Emerging Implications for Extracellular Matrix-Based Technologies in Vascularized Composite Allotransplantation
Despite recent progress in vascularized composite allotransplantation (VCA), limitations including complex, high dose immunosuppression regimens, lifelong risk of toxicity from immunosuppressants, acute and most critically chronic graft rejection, and suboptimal nerve regeneration remain particularl...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/1541823 |
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| _version_ | 1832554257670209536 |
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| author | Ricardo Londono Vijay S. Gorantla Stephen F. Badylak |
| author_facet | Ricardo Londono Vijay S. Gorantla Stephen F. Badylak |
| author_sort | Ricardo Londono |
| collection | DOAJ |
| description | Despite recent progress in vascularized composite allotransplantation (VCA), limitations including complex, high dose immunosuppression regimens, lifelong risk of toxicity from immunosuppressants, acute and most critically chronic graft rejection, and suboptimal nerve regeneration remain particularly challenging obstacles restricting clinical progress. When properly configured, customized, and implemented, biomaterials derived from the extracellular matrix (ECM) retain bioactive molecules and immunomodulatory properties that can promote stem cell migration, proliferation and differentiation, and constructive functional tissue remodeling. The present paper reviews the emerging implications of ECM-based technologies in VCA, including local immunomodulation, tissue repair, nerve regeneration, minimally invasive graft targeted drug delivery, stem cell transplantation, and other donor graft manipulation. |
| format | Article |
| id | doaj-art-e0898e30dd174fdb99576b0b12820421 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-e0898e30dd174fdb99576b0b128204212025-02-03T05:52:02ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/15418231541823Emerging Implications for Extracellular Matrix-Based Technologies in Vascularized Composite AllotransplantationRicardo Londono0Vijay S. Gorantla1Stephen F. Badylak2McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 152192, USAMcGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 152192, USAMcGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 152192, USADespite recent progress in vascularized composite allotransplantation (VCA), limitations including complex, high dose immunosuppression regimens, lifelong risk of toxicity from immunosuppressants, acute and most critically chronic graft rejection, and suboptimal nerve regeneration remain particularly challenging obstacles restricting clinical progress. When properly configured, customized, and implemented, biomaterials derived from the extracellular matrix (ECM) retain bioactive molecules and immunomodulatory properties that can promote stem cell migration, proliferation and differentiation, and constructive functional tissue remodeling. The present paper reviews the emerging implications of ECM-based technologies in VCA, including local immunomodulation, tissue repair, nerve regeneration, minimally invasive graft targeted drug delivery, stem cell transplantation, and other donor graft manipulation.http://dx.doi.org/10.1155/2016/1541823 |
| spellingShingle | Ricardo Londono Vijay S. Gorantla Stephen F. Badylak Emerging Implications for Extracellular Matrix-Based Technologies in Vascularized Composite Allotransplantation Stem Cells International |
| title | Emerging Implications for Extracellular Matrix-Based Technologies in Vascularized Composite Allotransplantation |
| title_full | Emerging Implications for Extracellular Matrix-Based Technologies in Vascularized Composite Allotransplantation |
| title_fullStr | Emerging Implications for Extracellular Matrix-Based Technologies in Vascularized Composite Allotransplantation |
| title_full_unstemmed | Emerging Implications for Extracellular Matrix-Based Technologies in Vascularized Composite Allotransplantation |
| title_short | Emerging Implications for Extracellular Matrix-Based Technologies in Vascularized Composite Allotransplantation |
| title_sort | emerging implications for extracellular matrix based technologies in vascularized composite allotransplantation |
| url | http://dx.doi.org/10.1155/2016/1541823 |
| work_keys_str_mv | AT ricardolondono emergingimplicationsforextracellularmatrixbasedtechnologiesinvascularizedcompositeallotransplantation AT vijaysgorantla emergingimplicationsforextracellularmatrixbasedtechnologiesinvascularizedcompositeallotransplantation AT stephenfbadylak emergingimplicationsforextracellularmatrixbasedtechnologiesinvascularizedcompositeallotransplantation |