Donor-Derived Urothelial Carcinoma in Renal Transplant Recipients
Cancer is a significant cause of morbidity and mortality in recipients of renal transplantation. The vast majority develop from recipient origins, whereas donor-derived malignancies are exceedingly rare. We report 2 cases of poorly differentiated donor-derived urothelial carcinoma (UC) in renal tran...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Urology |
| Online Access: | http://dx.doi.org/10.1155/2022/3353268 |
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| author | Zhiyu Qian Emily Chou Jing Yang Hanwei Zhang HuiHui Ye Sandy T. Liu Arnold I. Chin |
| author_facet | Zhiyu Qian Emily Chou Jing Yang Hanwei Zhang HuiHui Ye Sandy T. Liu Arnold I. Chin |
| author_sort | Zhiyu Qian |
| collection | DOAJ |
| description | Cancer is a significant cause of morbidity and mortality in recipients of renal transplantation. The vast majority develop from recipient origins, whereas donor-derived malignancies are exceedingly rare. We report 2 cases of poorly differentiated donor-derived urothelial carcinoma (UC) in renal transplantation recipients. The first patient underwent a living-related-donor renal transplantation 24 years prior and presented with back pain, hematuria, and rising creatinine and was found to have a 14 cm mass in the renal allograft with regional lymphadenopathy and liver metastases. Pathology showed UC with small-cell differentiation. The second patient presented with hematuria and rising creatinine and was initially found to have muscle invasive bladder cancer seven years after a deceased donor renal transplantation. Nine months after radical cystectomy, a large 9 cm mass was found on his allograft, for which radical nephrectomy and excision of prior ileal conduit was performed. Pathology showed UC with sarcomatoid differentiation. Short tandem repeat (STR) genotyping confirmed donor-derived origins. Both patient tumors expressed PD-L1 suggesting an additional therapeutic avenue for these rare tumors. |
| format | Article |
| id | doaj-art-e081ff037aa643c68a4e9acdc3c0c0cc |
| institution | Kabale University |
| issn | 2090-6978 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Urology |
| spelling | doaj-art-e081ff037aa643c68a4e9acdc3c0c0cc2025-02-03T01:10:36ZengWileyCase Reports in Urology2090-69782022-01-01202210.1155/2022/3353268Donor-Derived Urothelial Carcinoma in Renal Transplant RecipientsZhiyu Qian0Emily Chou1Jing Yang2Hanwei Zhang3HuiHui Ye4Sandy T. Liu5Arnold I. Chin6Division of UrologyDepartment of UrologyDepartment of PathologyDepartment of UrologyDepartment of PathologyDepartment of MedicineDepartment of UrologyCancer is a significant cause of morbidity and mortality in recipients of renal transplantation. The vast majority develop from recipient origins, whereas donor-derived malignancies are exceedingly rare. We report 2 cases of poorly differentiated donor-derived urothelial carcinoma (UC) in renal transplantation recipients. The first patient underwent a living-related-donor renal transplantation 24 years prior and presented with back pain, hematuria, and rising creatinine and was found to have a 14 cm mass in the renal allograft with regional lymphadenopathy and liver metastases. Pathology showed UC with small-cell differentiation. The second patient presented with hematuria and rising creatinine and was initially found to have muscle invasive bladder cancer seven years after a deceased donor renal transplantation. Nine months after radical cystectomy, a large 9 cm mass was found on his allograft, for which radical nephrectomy and excision of prior ileal conduit was performed. Pathology showed UC with sarcomatoid differentiation. Short tandem repeat (STR) genotyping confirmed donor-derived origins. Both patient tumors expressed PD-L1 suggesting an additional therapeutic avenue for these rare tumors.http://dx.doi.org/10.1155/2022/3353268 |
| spellingShingle | Zhiyu Qian Emily Chou Jing Yang Hanwei Zhang HuiHui Ye Sandy T. Liu Arnold I. Chin Donor-Derived Urothelial Carcinoma in Renal Transplant Recipients Case Reports in Urology |
| title | Donor-Derived Urothelial Carcinoma in Renal Transplant Recipients |
| title_full | Donor-Derived Urothelial Carcinoma in Renal Transplant Recipients |
| title_fullStr | Donor-Derived Urothelial Carcinoma in Renal Transplant Recipients |
| title_full_unstemmed | Donor-Derived Urothelial Carcinoma in Renal Transplant Recipients |
| title_short | Donor-Derived Urothelial Carcinoma in Renal Transplant Recipients |
| title_sort | donor derived urothelial carcinoma in renal transplant recipients |
| url | http://dx.doi.org/10.1155/2022/3353268 |
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