DNMT1 blocks SOX21-repressed CKS2 transcription to promote gastric cancer progression

DNMT1 blocks SOX21-repressed CKS2 transcription to promote gastric cancer progression

Abstract Background The dysregulation of SOXs is related to tumor invasion, metastasis, proliferation, apoptosis, and epithelial-mesenchymal transition. This research sought to investigate the function and mechanisms of SOX21 in gastric cancer (GC). Methods Multiple databases were included to determ...

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Bibliographic Details
Main Authors: Jie Wei, Song Xue, Xinglong Du, Yuanfei Dai, Yuting Ji, Guangsi He
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Cancer
Subjects:
Gastric cancer
DNMT1
SOX21
CKS2
Hypermethylation
Online Access:https://doi.org/10.1186/s12885-025-14577-z
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