A Porous TiAl6V4 Implant Material for Medical Application
Increased durability of permanent TiAl6V4 implants still remains a requirement for the patient’s well-being. One way to achieve a better bone-material connection is to enable bone “ingrowth” into the implant. Therefore, a new porous TiAl6V4 material was produced via metal injection moulding (MIM). S...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Biomaterials |
| Online Access: | http://dx.doi.org/10.1155/2014/904230 |
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| author | Axel Deing Bérengère Luthringer Daniel Laipple Thomas Ebel Regine Willumeit |
| author_facet | Axel Deing Bérengère Luthringer Daniel Laipple Thomas Ebel Regine Willumeit |
| author_sort | Axel Deing |
| collection | DOAJ |
| description | Increased durability of permanent TiAl6V4 implants still remains a requirement for the patient’s well-being. One way to achieve a better bone-material connection is to enable bone “ingrowth” into the implant. Therefore, a new porous TiAl6V4 material was produced via metal injection moulding (MIM). Specimens with four different porosities were produced using gas-atomised spherical TiAl6V4 with different powder particle diameters, namely, “Small” (<45 μm), “Medium” (45–63 μm), “Mix” (90% 125–180 μm + 10% <45 μm), and “Large” (125–180 μm). Tensile tests, compression tests, and resonant ultrasound spectroscopy (RUS) were used to analyse mechanical properties. These tests revealed an increasing Young’s modulus with decreasing porosity; that is, “Large” and “Mix” exhibit mechanical properties closer to bone than to bulk material. By applying X-ray tomography (3D volume) and optical metallographic methods (2D volume and dimensions) the pores were dissected. The pore analysis of the “Mix” and “Large” samples showed pore volumes between 29% and 34%, respectively, with pore diameters ranging up to 175 μm and even above 200 μm for “Large.” Material cytotoxicity on bone cell lines (SaOs-2 and MG-63) and primary cells (human bone-derived cells, HBDC) was studied by MTT assays and highlighted an increasing viability with higher porosity. |
| format | Article |
| id | doaj-art-e07edbd9bd3443e497a27049f3fc9fce |
| institution | Kabale University |
| issn | 1687-8787 1687-8795 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomaterials |
| spelling | doaj-art-e07edbd9bd3443e497a27049f3fc9fce2025-02-03T01:23:41ZengWileyInternational Journal of Biomaterials1687-87871687-87952014-01-01201410.1155/2014/904230904230A Porous TiAl6V4 Implant Material for Medical ApplicationAxel Deing0Bérengère Luthringer1Daniel Laipple2Thomas Ebel3Regine Willumeit4Institute of Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Straße 1, 21502 Geesthacht, GermanyInstitute of Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Straße 1, 21502 Geesthacht, GermanyInstitute of Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Straße 1, 21502 Geesthacht, GermanyInstitute of Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Straße 1, 21502 Geesthacht, GermanyInstitute of Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Straße 1, 21502 Geesthacht, GermanyIncreased durability of permanent TiAl6V4 implants still remains a requirement for the patient’s well-being. One way to achieve a better bone-material connection is to enable bone “ingrowth” into the implant. Therefore, a new porous TiAl6V4 material was produced via metal injection moulding (MIM). Specimens with four different porosities were produced using gas-atomised spherical TiAl6V4 with different powder particle diameters, namely, “Small” (<45 μm), “Medium” (45–63 μm), “Mix” (90% 125–180 μm + 10% <45 μm), and “Large” (125–180 μm). Tensile tests, compression tests, and resonant ultrasound spectroscopy (RUS) were used to analyse mechanical properties. These tests revealed an increasing Young’s modulus with decreasing porosity; that is, “Large” and “Mix” exhibit mechanical properties closer to bone than to bulk material. By applying X-ray tomography (3D volume) and optical metallographic methods (2D volume and dimensions) the pores were dissected. The pore analysis of the “Mix” and “Large” samples showed pore volumes between 29% and 34%, respectively, with pore diameters ranging up to 175 μm and even above 200 μm for “Large.” Material cytotoxicity on bone cell lines (SaOs-2 and MG-63) and primary cells (human bone-derived cells, HBDC) was studied by MTT assays and highlighted an increasing viability with higher porosity.http://dx.doi.org/10.1155/2014/904230 |
| spellingShingle | Axel Deing Bérengère Luthringer Daniel Laipple Thomas Ebel Regine Willumeit A Porous TiAl6V4 Implant Material for Medical Application International Journal of Biomaterials |
| title | A Porous TiAl6V4 Implant Material for Medical Application |
| title_full | A Porous TiAl6V4 Implant Material for Medical Application |
| title_fullStr | A Porous TiAl6V4 Implant Material for Medical Application |
| title_full_unstemmed | A Porous TiAl6V4 Implant Material for Medical Application |
| title_short | A Porous TiAl6V4 Implant Material for Medical Application |
| title_sort | porous tial6v4 implant material for medical application |
| url | http://dx.doi.org/10.1155/2014/904230 |
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