Synthesis, characterization and cytotoxic evaluation of metal complexes derived from new N′-(2-cyanoacetyl)isonicotinohydrazide

Synthesis, characterization and cytotoxic evaluation of metal complexes derived from new N′-(2-cyanoacetyl)isonicotinohydrazide

Abstract The novel ligand (H2L), N’-(2-cyanoacetyl)isonicotinohydrazide, has been synthesized via reacting the isonicotinic hydrazide with 1-cyanoacetyl-3,5-dimethylpyrazole. The keto-form of the free ligand has been evoked from its spectral data. Based on elemental analyses and mass spectra, the li...

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Bibliographic Details
Main Authors:	Mohamed H. Abdel-Rhman, Ghada Samir, Nasser M. Hosny
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-06-01
Series:	Scientific Reports
Subjects:	Isoniazid Spectroscopic studies Chelation ligand DFT modeling Cytotoxicity activity
Online Access:	https://doi.org/10.1038/s41598-025-07689-w
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