Enaminone-Derived Pyrazoles with Antimicrobial Activity
A series of pyrazoles derived from the substituted enaminones were synthesized and were evaluated for antimicrobial activity. All the compounds were characterized by the spectral data and elemental analysis. The synthesized compounds were initially screened for their antimicrobial activity against A...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2019/2467970 |
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| author | Mashooq Ahmad Bhat Mohamed A. Al-Omar Ahmed M. Naglah Abdul Arif Khan |
| author_facet | Mashooq Ahmad Bhat Mohamed A. Al-Omar Ahmed M. Naglah Abdul Arif Khan |
| author_sort | Mashooq Ahmad Bhat |
| collection | DOAJ |
| description | A series of pyrazoles derived from the substituted enaminones were synthesized and were evaluated for antimicrobial activity. All the compounds were characterized by the spectral data and elemental analysis. The synthesized compounds were initially screened for their antimicrobial activity against ATCC 6538, NCTC 10400, NCTC 10418, and ATCC 27853. During initial screening, compounds (P1, P6, and P11) presented significant antimicrobial activity through disc diffusion assay. These compounds were further evaluated for antimicrobial activity at different time points against Gram-positive and Gram-negative bacteria and presented significant activity for 6 hours. The activity was found to be greater against Gram-positive bacteria. In contrast at 24 hours, the activity was found only against Gram-positive bacteria except compound (P11), showing activity against both types of bacteria. Compound (P11) was found to have highest activity against both Gram-positive and Gram-negative bacteria. |
| format | Article |
| id | doaj-art-e06df0e44f11420fa63d48a2a447302c |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-e06df0e44f11420fa63d48a2a447302c2025-02-03T05:59:31ZengWileyJournal of Chemistry2090-90632090-90712019-01-01201910.1155/2019/24679702467970Enaminone-Derived Pyrazoles with Antimicrobial ActivityMashooq Ahmad Bhat0Mohamed A. Al-Omar1Ahmed M. Naglah2Abdul Arif Khan3Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Pharmaceutical Chemistry, Drug Exploration and Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaA series of pyrazoles derived from the substituted enaminones were synthesized and were evaluated for antimicrobial activity. All the compounds were characterized by the spectral data and elemental analysis. The synthesized compounds were initially screened for their antimicrobial activity against ATCC 6538, NCTC 10400, NCTC 10418, and ATCC 27853. During initial screening, compounds (P1, P6, and P11) presented significant antimicrobial activity through disc diffusion assay. These compounds were further evaluated for antimicrobial activity at different time points against Gram-positive and Gram-negative bacteria and presented significant activity for 6 hours. The activity was found to be greater against Gram-positive bacteria. In contrast at 24 hours, the activity was found only against Gram-positive bacteria except compound (P11), showing activity against both types of bacteria. Compound (P11) was found to have highest activity against both Gram-positive and Gram-negative bacteria.http://dx.doi.org/10.1155/2019/2467970 |
| spellingShingle | Mashooq Ahmad Bhat Mohamed A. Al-Omar Ahmed M. Naglah Abdul Arif Khan Enaminone-Derived Pyrazoles with Antimicrobial Activity Journal of Chemistry |
| title | Enaminone-Derived Pyrazoles with Antimicrobial Activity |
| title_full | Enaminone-Derived Pyrazoles with Antimicrobial Activity |
| title_fullStr | Enaminone-Derived Pyrazoles with Antimicrobial Activity |
| title_full_unstemmed | Enaminone-Derived Pyrazoles with Antimicrobial Activity |
| title_short | Enaminone-Derived Pyrazoles with Antimicrobial Activity |
| title_sort | enaminone derived pyrazoles with antimicrobial activity |
| url | http://dx.doi.org/10.1155/2019/2467970 |
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