Single-cell transcriptome analysis identifies a novel tumor-associated macrophage subtype predicting better prognosis in pancreatic ductal adenocarcinoma

Single-cell transcriptome analysis identifies a novel tumor-associated macrophage subtype predicting better prognosis in pancreatic ductal adenocarcinoma

BackgroundCharacterized by an immune-suppressive tumor microenvironment (TME), pancreatic ductal adenocarcinoma (PDAC) is well-known for its poor prognosis. Tumor associated macrophages (TAMs) play a critical role in PDAC TME. An in-depth understanding of TAMs is helpful to develop new strategies fo...

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Bibliographic Details
Main Authors: Xiaonan Wang, Dongyi Li, Bo Zhu, Zichun Hua
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
single-cell sequencing
pancreatic cancer
tumor associated macrophages
tumor microenvironment
prognosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2024.1466767/full
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