Presentation of CXCL12γ by heparan sulfate proteoglycans activates CXCR4 without desensitization in normal and malignant B cells
Abstract: CXCL12-CXCR4 signaling is involved in a wide variety of homeostatic and pathologic processes, but the role of specific CXCL12 isoforms has remained largely unexplored. We have recently shown that the CXCL12γ isoform, which holds an exceptionally high affinity for heparan sulfate (HS), is p...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-05-01
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| Series: | Blood Advances |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2473952925001120 |
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