Presentation of CXCL12γ by heparan sulfate proteoglycans activates CXCR4 without desensitization in normal and malignant B cells

Presentation of CXCL12γ by heparan sulfate proteoglycans activates CXCR4 without desensitization in normal and malignant B cells

Abstract: CXCL12-CXCR4 signaling is involved in a wide variety of homeostatic and pathologic processes, but the role of specific CXCL12 isoforms has remained largely unexplored. We have recently shown that the CXCL12γ isoform, which holds an exceptionally high affinity for heparan sulfate (HS), is p...

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Main Authors: Hildo C. Lantermans, Fangxue Ma, Annemieke Kuil, Martin F. M. de Rooij, Nick D. Bergkamp, Werner van der Meer, Jaap D. van Buul, Martine J. Smit, Marie José Kersten, Marcel Spaargaren, Steven T. Pals
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Blood Advances
Online Access:http://www.sciencedirect.com/science/article/pii/S2473952925001120
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http://www.sciencedirect.com/science/article/pii/S2473952925001120

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