Amphetamine Derivatives as Potent Central Nervous System Multitarget SERT/NET/H<sub>3</sub> Agents: Synthesis and Biological Evaluation

Amphetamine Derivatives as Potent Central Nervous System Multitarget SERT/NET/H<sub>3</sub> Agents: Synthesis and Biological Evaluation

In this research, a variety of novel amphetamine derivatives were synthesized and assessed for their potential as multifaceted antidepressant agents. Among these compounds, compound <b>11b</b> demonstrated potent inhibitory effects on both serotonin and noradrenaline transporters (SERT/N...

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Bibliographic Details
Main Authors: Quxiang Li, Lili Ren, Dongli Wang, Junyong Luo, Changda Xu, Jian Feng, Yufan Qiu, Xiangqing Xu, Guoguang Chen
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Molecules
Subjects:
amphetamine
multitarget
antidepressant
molecular docking
Online Access:https://www.mdpi.com/1420-3049/29/22/5240
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