Functional mass spectrometry indicates anti-protease and complement activity increase with COVID-19 severity

Functional mass spectrometry indicates anti-protease and complement activity increase with COVID-19 severity

Investigations on some innate immunity proteins can yield misleading information, as investigators often rely on static measurements and assume a direct correlation to function. As protein function is often not directly proportional to protein abundance, and mechanistic pathways are interconnected a...

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Bibliographic Details
Main Authors: Douglas D. Fraser, Swapan Roy, Matt Kuruc, Maritza Quintero, Logan R. Van Nynatten, Gediminas Cepinskas, Haiyan Zheng, Amenah Soherwardy, Devjit Roy
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Experimental Biology and Medicine
Subjects:
COVID-19
functional mass spectrometry
neutrophil elastase
lymphocyte granzyme B
complement
Online Access:https://www.ebm-journal.org/articles/10.3389/ebm.2025.10308/full
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