Milled flaxseed-added diets ameliorated hepatic inflammation by reducing gene expression of TLR4/NF-κB pathway and altered gut microbiota in STZ-induced type 1 diabetic mice
Flaxseed has displayed the potential beneficial as functional foods. However, most studies focused on effects of flaxseed extracts or ingredients in flaxseed. Besides, few studies showed that flaxseed extracts contributed to anti-type 1 diabetes (T1D), yet the underlying mechanism is still unknown....
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2022-01-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453021000707 |
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| author | Hui Xia Xiangling Shi Beijia Zhou Jing Sui Chao Yang Hechun Liu Ligang Yang Shaokang Wang Guiju Sun |
| author_facet | Hui Xia Xiangling Shi Beijia Zhou Jing Sui Chao Yang Hechun Liu Ligang Yang Shaokang Wang Guiju Sun |
| author_sort | Hui Xia |
| collection | DOAJ |
| description | Flaxseed has displayed the potential beneficial as functional foods. However, most studies focused on effects of flaxseed extracts or ingredients in flaxseed. Besides, few studies showed that flaxseed extracts contributed to anti-type 1 diabetes (T1D), yet the underlying mechanism is still unknown. In the present study, 16.7% of milled flaxseed (MF)-added diet was given to diabetic mice induced by streptozocin for 6 weeks. The results showed that MF feeding 1) slightly decreased blood glucose levels and improved the ability of glucose tolerance by oral glucose tolerance test, 2) decreased liver tumor necrosis factor-α levels and increased liver glycogen levels with significance via down-regulating TLR4/NF-κB pathways, 3) and significantly altered some beneficial bacteria in gut microbiota. In conclusion, the present study showed that milled flaxseed showed the potential on anti-T1D through anti-inflammation via TLR4/NF-κB and altering the gut microbiota in STZ-induced diabetic mice. |
| format | Article |
| id | doaj-art-e043d5d5d7624957a030e223ee581ce3 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-e043d5d5d7624957a030e223ee581ce32025-02-03T00:27:31ZengTsinghua University PressFood Science and Human Wellness2213-45302022-01-011113240Milled flaxseed-added diets ameliorated hepatic inflammation by reducing gene expression of TLR4/NF-κB pathway and altered gut microbiota in STZ-induced type 1 diabetic miceHui Xia0Xiangling Shi1Beijia Zhou2Jing Sui3Chao Yang4Hechun Liu5Ligang Yang6Shaokang Wang7Guiju Sun8Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, ChinaResearch Institute for Environment and Health, School of Law and Public Affairs, Nanjing University of Information Science and Technology, Nanjing, Jiangsu, 210044, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China; Corresponding author at: Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food hygiene, School of Public Health, Southeast University, Nanjing 210009, China.Flaxseed has displayed the potential beneficial as functional foods. However, most studies focused on effects of flaxseed extracts or ingredients in flaxseed. Besides, few studies showed that flaxseed extracts contributed to anti-type 1 diabetes (T1D), yet the underlying mechanism is still unknown. In the present study, 16.7% of milled flaxseed (MF)-added diet was given to diabetic mice induced by streptozocin for 6 weeks. The results showed that MF feeding 1) slightly decreased blood glucose levels and improved the ability of glucose tolerance by oral glucose tolerance test, 2) decreased liver tumor necrosis factor-α levels and increased liver glycogen levels with significance via down-regulating TLR4/NF-κB pathways, 3) and significantly altered some beneficial bacteria in gut microbiota. In conclusion, the present study showed that milled flaxseed showed the potential on anti-T1D through anti-inflammation via TLR4/NF-κB and altering the gut microbiota in STZ-induced diabetic mice.http://www.sciencedirect.com/science/article/pii/S2213453021000707Milled flaxseedType 1 diabetesGut microbiotaTLR4/NF-κB pathway |
| spellingShingle | Hui Xia Xiangling Shi Beijia Zhou Jing Sui Chao Yang Hechun Liu Ligang Yang Shaokang Wang Guiju Sun Milled flaxseed-added diets ameliorated hepatic inflammation by reducing gene expression of TLR4/NF-κB pathway and altered gut microbiota in STZ-induced type 1 diabetic mice Food Science and Human Wellness Milled flaxseed Type 1 diabetes Gut microbiota TLR4/NF-κB pathway |
| title | Milled flaxseed-added diets ameliorated hepatic inflammation by reducing gene expression of TLR4/NF-κB pathway and altered gut microbiota in STZ-induced type 1 diabetic mice |
| title_full | Milled flaxseed-added diets ameliorated hepatic inflammation by reducing gene expression of TLR4/NF-κB pathway and altered gut microbiota in STZ-induced type 1 diabetic mice |
| title_fullStr | Milled flaxseed-added diets ameliorated hepatic inflammation by reducing gene expression of TLR4/NF-κB pathway and altered gut microbiota in STZ-induced type 1 diabetic mice |
| title_full_unstemmed | Milled flaxseed-added diets ameliorated hepatic inflammation by reducing gene expression of TLR4/NF-κB pathway and altered gut microbiota in STZ-induced type 1 diabetic mice |
| title_short | Milled flaxseed-added diets ameliorated hepatic inflammation by reducing gene expression of TLR4/NF-κB pathway and altered gut microbiota in STZ-induced type 1 diabetic mice |
| title_sort | milled flaxseed added diets ameliorated hepatic inflammation by reducing gene expression of tlr4 nf κb pathway and altered gut microbiota in stz induced type 1 diabetic mice |
| topic | Milled flaxseed Type 1 diabetes Gut microbiota TLR4/NF-κB pathway |
| url | http://www.sciencedirect.com/science/article/pii/S2213453021000707 |
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