FTIR Spectrophotometry as a Green Tool for Quantitative Analysis of Drugs: Practical Application to Amoxicillin
Amoxicillin is an antimicrobial agent that belongs to the penicillin compounds. Its bactericidal action causes a destruction of the cell wall of bacteria. It is widely used in clinical practice, and it belongs to the Brazilian National List of Essential Drugs (RENAME). In literature, there are some...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2018/3920810 |
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| author | Stefany Fanelli Alexander Zimmermann Eliane Gandolpho Totóli Hérida Regina Nunes Salgado |
| author_facet | Stefany Fanelli Alexander Zimmermann Eliane Gandolpho Totóli Hérida Regina Nunes Salgado |
| author_sort | Stefany Fanelli |
| collection | DOAJ |
| description | Amoxicillin is an antimicrobial agent that belongs to the penicillin compounds. Its bactericidal action causes a destruction of the cell wall of bacteria. It is widely used in clinical practice, and it belongs to the Brazilian National List of Essential Drugs (RENAME). In literature, there are some green analytical methods for the amoxicillin analysis; however, none of them is focused on its quantification in capsules. Therefore, the aim of this study was to validate an environmentally friendly analytical method for the analysis of this antimicrobial action in capsules, using spectrophotometry in the mid-infrared region. The analyses were performed in the spectral range of 1815–1736 cm−1, and the samples were analyzed as potassium bromide pellets. The method was validated according to the ICH guidelines and Brazilian legislation. Linearity, selectivity, precision, accuracy, and robustness were evaluated and showed adequate results for method validation, in a concentration range of 0.5–1.5 mg/pellet. Thus, it is concluded that the validated spectrophotometric method is able to quantify amoxicillin in capsules. In addition, it is a fast, economical, and environmentally friendly method, since it does not use organic solvents, and it can be used for quality control of routine analysis of this drug. |
| format | Article |
| id | doaj-art-e03fb0e5cd1349debc0b165aa45d9d5d |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
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| series | Journal of Chemistry |
| spelling | doaj-art-e03fb0e5cd1349debc0b165aa45d9d5d2025-02-03T01:03:29ZengWileyJournal of Chemistry2090-90632090-90712018-01-01201810.1155/2018/39208103920810FTIR Spectrophotometry as a Green Tool for Quantitative Analysis of Drugs: Practical Application to AmoxicillinStefany Fanelli0Alexander Zimmermann1Eliane Gandolpho Totóli2Hérida Regina Nunes Salgado3School of Pharmaceutical Sciences, Universidade Estadual Paulista, Araraquara, SP, BrazilInstitute of Biochemistry and Biotechnology, Faculty of Natural Science I, Martin-Luther-University Halle-Wittenberg, Halle (Saale), GermanySchool of Pharmaceutical Sciences, Universidade Estadual Paulista, Araraquara, SP, BrazilSchool of Pharmaceutical Sciences, Universidade Estadual Paulista, Araraquara, SP, BrazilAmoxicillin is an antimicrobial agent that belongs to the penicillin compounds. Its bactericidal action causes a destruction of the cell wall of bacteria. It is widely used in clinical practice, and it belongs to the Brazilian National List of Essential Drugs (RENAME). In literature, there are some green analytical methods for the amoxicillin analysis; however, none of them is focused on its quantification in capsules. Therefore, the aim of this study was to validate an environmentally friendly analytical method for the analysis of this antimicrobial action in capsules, using spectrophotometry in the mid-infrared region. The analyses were performed in the spectral range of 1815–1736 cm−1, and the samples were analyzed as potassium bromide pellets. The method was validated according to the ICH guidelines and Brazilian legislation. Linearity, selectivity, precision, accuracy, and robustness were evaluated and showed adequate results for method validation, in a concentration range of 0.5–1.5 mg/pellet. Thus, it is concluded that the validated spectrophotometric method is able to quantify amoxicillin in capsules. In addition, it is a fast, economical, and environmentally friendly method, since it does not use organic solvents, and it can be used for quality control of routine analysis of this drug.http://dx.doi.org/10.1155/2018/3920810 |
| spellingShingle | Stefany Fanelli Alexander Zimmermann Eliane Gandolpho Totóli Hérida Regina Nunes Salgado FTIR Spectrophotometry as a Green Tool for Quantitative Analysis of Drugs: Practical Application to Amoxicillin Journal of Chemistry |
| title | FTIR Spectrophotometry as a Green Tool for Quantitative Analysis of Drugs: Practical Application to Amoxicillin |
| title_full | FTIR Spectrophotometry as a Green Tool for Quantitative Analysis of Drugs: Practical Application to Amoxicillin |
| title_fullStr | FTIR Spectrophotometry as a Green Tool for Quantitative Analysis of Drugs: Practical Application to Amoxicillin |
| title_full_unstemmed | FTIR Spectrophotometry as a Green Tool for Quantitative Analysis of Drugs: Practical Application to Amoxicillin |
| title_short | FTIR Spectrophotometry as a Green Tool for Quantitative Analysis of Drugs: Practical Application to Amoxicillin |
| title_sort | ftir spectrophotometry as a green tool for quantitative analysis of drugs practical application to amoxicillin |
| url | http://dx.doi.org/10.1155/2018/3920810 |
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