Unraveling Demographic Patterns in Hepatitis B Clinical and Laboratory Profiles: Insights From a Ghanaian Cohort: A Retrospective Study
ABSTRACT Background and Aims The influence of age and gender on the manifestations of Hepatitis B (HB) disease is underexplored and yields varied findings. This study assessed the impact of age and gender on HB disease manifestations in a Ghanaian population. Methods This retrospective study evaluat...
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Wiley
2025-04-01
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| Series: | Health Science Reports |
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| Online Access: | https://doi.org/10.1002/hsr2.70689 |
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| author | Napoleon Bellua Sam Saeed Folorunsho Majeed Adams Dramani |
| author_facet | Napoleon Bellua Sam Saeed Folorunsho Majeed Adams Dramani |
| author_sort | Napoleon Bellua Sam |
| collection | DOAJ |
| description | ABSTRACT Background and Aims The influence of age and gender on the manifestations of Hepatitis B (HB) disease is underexplored and yields varied findings. This study assessed the impact of age and gender on HB disease manifestations in a Ghanaian population. Methods This retrospective study evaluated 569 patients at Tamale Teaching Hospital. Disease manifestations were compared separately between male and female patients across different age groups and among four distinct age groups within male and female patients. Results It revealed a male‐to‐female ratio of 5.1:1, with significant differences observed among age categories. HBsAg was significantly more prevalent in adult males (p < 0.05), while polydipsia showed equal prevalence between genders (p < 0.05). Female adults exhibited higher rates of constipation and palpitation compared to males (p < 0.05). In older patients, females had higher ALT and HBeAg prevalence than males (p < 0.05). Disease manifestation did not significantly differ by gender among children and younger patients (p > 0.05). Among males, viral load differed significantly across age groups and correlated positively with age (p < 0.05). Females showed positive correlations of jaundice, HBeAg, low globulin, and high AST with age (p < 0.05), but nausea was negatively correlated (p < 0.05). Conclusion This study highlights unique clinical and laboratory features in reproductive‐aged female HB patients. |
| format | Article |
| id | doaj-art-e039190673dc4c75a67cdfd73efbf39e |
| institution | DOAJ |
| issn | 2398-8835 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj-art-e039190673dc4c75a67cdfd73efbf39e2025-08-20T03:11:58ZengWileyHealth Science Reports2398-88352025-04-0184n/an/a10.1002/hsr2.70689Unraveling Demographic Patterns in Hepatitis B Clinical and Laboratory Profiles: Insights From a Ghanaian Cohort: A Retrospective StudyNapoleon Bellua Sam0Saeed Folorunsho Majeed1Adams Dramani2Department of Medical Research and Innovation School of Medicine, University for Development Studies Tamale GhanaDepartment of Biological Science Faculty of Biosciences, University for Development Studies Tamale GhanaDepartment of Medical Research and Innovation School of Medicine, University for Development Studies Tamale GhanaABSTRACT Background and Aims The influence of age and gender on the manifestations of Hepatitis B (HB) disease is underexplored and yields varied findings. This study assessed the impact of age and gender on HB disease manifestations in a Ghanaian population. Methods This retrospective study evaluated 569 patients at Tamale Teaching Hospital. Disease manifestations were compared separately between male and female patients across different age groups and among four distinct age groups within male and female patients. Results It revealed a male‐to‐female ratio of 5.1:1, with significant differences observed among age categories. HBsAg was significantly more prevalent in adult males (p < 0.05), while polydipsia showed equal prevalence between genders (p < 0.05). Female adults exhibited higher rates of constipation and palpitation compared to males (p < 0.05). In older patients, females had higher ALT and HBeAg prevalence than males (p < 0.05). Disease manifestation did not significantly differ by gender among children and younger patients (p > 0.05). Among males, viral load differed significantly across age groups and correlated positively with age (p < 0.05). Females showed positive correlations of jaundice, HBeAg, low globulin, and high AST with age (p < 0.05), but nausea was negatively correlated (p < 0.05). Conclusion This study highlights unique clinical and laboratory features in reproductive‐aged female HB patients.https://doi.org/10.1002/hsr2.70689agedisease manifestationsgenderhepatitis BTamale Teaching Hospital |
| spellingShingle | Napoleon Bellua Sam Saeed Folorunsho Majeed Adams Dramani Unraveling Demographic Patterns in Hepatitis B Clinical and Laboratory Profiles: Insights From a Ghanaian Cohort: A Retrospective Study Health Science Reports age disease manifestations gender hepatitis B Tamale Teaching Hospital |
| title | Unraveling Demographic Patterns in Hepatitis B Clinical and Laboratory Profiles: Insights From a Ghanaian Cohort: A Retrospective Study |
| title_full | Unraveling Demographic Patterns in Hepatitis B Clinical and Laboratory Profiles: Insights From a Ghanaian Cohort: A Retrospective Study |
| title_fullStr | Unraveling Demographic Patterns in Hepatitis B Clinical and Laboratory Profiles: Insights From a Ghanaian Cohort: A Retrospective Study |
| title_full_unstemmed | Unraveling Demographic Patterns in Hepatitis B Clinical and Laboratory Profiles: Insights From a Ghanaian Cohort: A Retrospective Study |
| title_short | Unraveling Demographic Patterns in Hepatitis B Clinical and Laboratory Profiles: Insights From a Ghanaian Cohort: A Retrospective Study |
| title_sort | unraveling demographic patterns in hepatitis b clinical and laboratory profiles insights from a ghanaian cohort a retrospective study |
| topic | age disease manifestations gender hepatitis B Tamale Teaching Hospital |
| url | https://doi.org/10.1002/hsr2.70689 |
| work_keys_str_mv | AT napoleonbelluasam unravelingdemographicpatternsinhepatitisbclinicalandlaboratoryprofilesinsightsfromaghanaiancohortaretrospectivestudy AT saeedfolorunshomajeed unravelingdemographicpatternsinhepatitisbclinicalandlaboratoryprofilesinsightsfromaghanaiancohortaretrospectivestudy AT adamsdramani unravelingdemographicpatternsinhepatitisbclinicalandlaboratoryprofilesinsightsfromaghanaiancohortaretrospectivestudy |