Primary Thrombotic Microangiopathy in Pediatric Patients
Background . Primary thrombotic microangiopathy includes hemolytic uremic syndrome caused by Shiga toxin-producing Escherichia coli , atypical hemolytic uremic syndrome, and thrombotic thrombocytopenic purpura. Methodology . A retrospective study that included patients younger than 18 years diagnose...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2024-12-01
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| Series: | Global Pediatric Health |
| Online Access: | https://doi.org/10.1177/2333794X241307535 |
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| _version_ | 1850114780285632512 |
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| author | Andrés David Aranzazu Ceballos MD Lina María Martínez Sánchez MSc Ana Paulina Pamplona Sierra MD Daniela Vergara Yánez MD Liliana Franco Hincapié PhD Richard Baquero Rodriguez MD |
| author_facet | Andrés David Aranzazu Ceballos MD Lina María Martínez Sánchez MSc Ana Paulina Pamplona Sierra MD Daniela Vergara Yánez MD Liliana Franco Hincapié PhD Richard Baquero Rodriguez MD |
| author_sort | Andrés David Aranzazu Ceballos MD |
| collection | DOAJ |
| description | Background . Primary thrombotic microangiopathy includes hemolytic uremic syndrome caused by Shiga toxin-producing Escherichia coli , atypical hemolytic uremic syndrome, and thrombotic thrombocytopenic purpura. Methodology . A retrospective study that included patients younger than 18 years diagnosed with primary thrombotic microangiopathy between 2011 and 2021. Results . Thirty patients were included, of which 63% corresponded to a hemolytic uremic syndrome caused by Shiga toxin-producing Escherichia coli , and 30% to the atypical hemolytic uremic syndrome. The median age was 2.8 years and female sex predominated at 57%. On admission to the emergency room, fever and fatigue were the most frequent symptoms (93%), followed by oliguria and anuria (80%). 48% of patients received hemodialysis during their care. Mortality was estimated at 13%. Conclusion . This study constitutes the largest series of primary thrombotic microangiopathy in the pediatric population of Latin America, where the etiological and clinical behavior of this condition is described. |
| format | Article |
| id | doaj-art-e036b4bca445491a9df0dbb6f8ecabd3 |
| institution | OA Journals |
| issn | 2333-794X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Global Pediatric Health |
| spelling | doaj-art-e036b4bca445491a9df0dbb6f8ecabd32025-08-20T02:36:45ZengSAGE PublishingGlobal Pediatric Health2333-794X2024-12-011110.1177/2333794X241307535Primary Thrombotic Microangiopathy in Pediatric PatientsAndrés David Aranzazu Ceballos MD0Lina María Martínez Sánchez MSc1Ana Paulina Pamplona Sierra MD2Daniela Vergara Yánez MD3Liliana Franco Hincapié PhD4Richard Baquero Rodriguez MD5Universidad Pontificia Bolivariana, Medellín, ColombiaUniversidad Pontificia Bolivariana, Medellín, ColombiaHospital Pablo Tobón Uribe, Medellín, ColombiaUniversidad Pontificia Bolivariana, Medellín, ColombiaUniversidad Pontificia Bolivariana, Medellín, ColombiaHospital Universitario San Vicente Fundacion, Antioquia, ColombiaBackground . Primary thrombotic microangiopathy includes hemolytic uremic syndrome caused by Shiga toxin-producing Escherichia coli , atypical hemolytic uremic syndrome, and thrombotic thrombocytopenic purpura. Methodology . A retrospective study that included patients younger than 18 years diagnosed with primary thrombotic microangiopathy between 2011 and 2021. Results . Thirty patients were included, of which 63% corresponded to a hemolytic uremic syndrome caused by Shiga toxin-producing Escherichia coli , and 30% to the atypical hemolytic uremic syndrome. The median age was 2.8 years and female sex predominated at 57%. On admission to the emergency room, fever and fatigue were the most frequent symptoms (93%), followed by oliguria and anuria (80%). 48% of patients received hemodialysis during their care. Mortality was estimated at 13%. Conclusion . This study constitutes the largest series of primary thrombotic microangiopathy in the pediatric population of Latin America, where the etiological and clinical behavior of this condition is described.https://doi.org/10.1177/2333794X241307535 |
| spellingShingle | Andrés David Aranzazu Ceballos MD Lina María Martínez Sánchez MSc Ana Paulina Pamplona Sierra MD Daniela Vergara Yánez MD Liliana Franco Hincapié PhD Richard Baquero Rodriguez MD Primary Thrombotic Microangiopathy in Pediatric Patients Global Pediatric Health |
| title | Primary Thrombotic Microangiopathy in Pediatric Patients |
| title_full | Primary Thrombotic Microangiopathy in Pediatric Patients |
| title_fullStr | Primary Thrombotic Microangiopathy in Pediatric Patients |
| title_full_unstemmed | Primary Thrombotic Microangiopathy in Pediatric Patients |
| title_short | Primary Thrombotic Microangiopathy in Pediatric Patients |
| title_sort | primary thrombotic microangiopathy in pediatric patients |
| url | https://doi.org/10.1177/2333794X241307535 |
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