2H-1,4-Benzoxazin-3(4H)-one linked 1,2,3-triazole derivatives and their study on inducing DNA damage in tumor cells

2H-1,4-Benzoxazin-3(4H)-one linked 1,2,3-triazole derivatives and their study on inducing DNA damage in tumor cells

This study explores the anticancer potential of rigid planar compounds capable of intercalating into tumor cell DNA, thereby inducing DNA damage and subsequent cell death. A novel series of compounds (c1–c20) were synthesized using 2H-1,4-benzoxazin-3(4H)-one as the planar core structure, with 1,2,3...

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Bibliographic Details
Main Authors: Xixi Hou, Yajie Guo, Xi Wang, En Gao, Jianxue Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
2H-1
4-benzoxazin-3(4H)-one
1,2,3-triazole
anti-tumor DNA damage
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1564090/full
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