Pulmonary hemorrhage and hemopneumothorax following the administration of lenvatinib for lung metastasis from hepatocellular carcinoma
A 71-year-old man was started on 12 mg/day of lenvatinib for lung metastasis from hepatocellular carcinoma (HCC). The day after starting treatment, he developed hemoptysis, and a CT scan revealed a rupture of the left upper lobe metastasis, accompanied by pulmonary hemorrhage. Angiography was perfor...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Respiratory Medicine Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213007125000693 |
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| author | Kazuya Kishimoto Nobuhiro Izumi Hirotaka Kinoshita Takuya Tanimura Satoshi Suzuki Kantaro Hara Hidetoshi Inoue Takuma Tsukioka Masanori Shiohara Naoshi Odagiri Junichi Soh |
| author_facet | Kazuya Kishimoto Nobuhiro Izumi Hirotaka Kinoshita Takuya Tanimura Satoshi Suzuki Kantaro Hara Hidetoshi Inoue Takuma Tsukioka Masanori Shiohara Naoshi Odagiri Junichi Soh |
| author_sort | Kazuya Kishimoto |
| collection | DOAJ |
| description | A 71-year-old man was started on 12 mg/day of lenvatinib for lung metastasis from hepatocellular carcinoma (HCC). The day after starting treatment, he developed hemoptysis, and a CT scan revealed a rupture of the left upper lobe metastasis, accompanied by pulmonary hemorrhage. Angiography was performed, and the responsible blood vessels, the bronchial artery and the left pulmonary artery (A1+2ab), were embolized. One week later, the patient developed a left tension pneumothorax. Despite thoracic drainage, air leakage and bloody drainage persisted. We decided to perform a left upper lobe resection to control the bleeding and air leakage. A 10-cm necrotic lesion was found in the left upper lobe, and the pleura between the lobes had ruptured, causing a hematoma to drain into the pleural cavity. We encountered a case of hemopneumothorax resulting from the rupture of lung metastases from HCC during treatment with lenvatinib. |
| format | Article |
| id | doaj-art-e0204e68d866458dbf7f19dc2a05ab51 |
| institution | Kabale University |
| issn | 2213-0071 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Respiratory Medicine Case Reports |
| spelling | doaj-art-e0204e68d866458dbf7f19dc2a05ab512025-08-20T03:30:15ZengElsevierRespiratory Medicine Case Reports2213-00712025-01-015610223310.1016/j.rmcr.2025.102233Pulmonary hemorrhage and hemopneumothorax following the administration of lenvatinib for lung metastasis from hepatocellular carcinomaKazuya Kishimoto0Nobuhiro Izumi1Hirotaka Kinoshita2Takuya Tanimura3Satoshi Suzuki4Kantaro Hara5Hidetoshi Inoue6Takuma Tsukioka7Masanori Shiohara8Naoshi Odagiri9Junichi Soh10Department of Thoracic Surgery, Graduate School of Medicine, Osaka Metropolitan University, Osaka, JapanDepartment of Thoracic Surgery, Graduate School of Medicine, Osaka Metropolitan University, Osaka, JapanDepartment of Thoracic Surgery, Graduate School of Medicine, Osaka Metropolitan University, Osaka, JapanDepartment of Thoracic Surgery, Graduate School of Medicine, Osaka Metropolitan University, Osaka, JapanDepartment of Thoracic Surgery, Graduate School of Medicine, Osaka Metropolitan University, Osaka, JapanDepartment of Thoracic Surgery, Graduate School of Medicine, Osaka Metropolitan University, Osaka, JapanDepartment of Thoracic Surgery, Graduate School of Medicine, Osaka Metropolitan University, Osaka, JapanDepartment of Thoracic Surgery, Graduate School of Medicine, Osaka Metropolitan University, Osaka, JapanDepartment of Pathology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, JapanDepartment of Hepatology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, JapanDepartment of Thoracic Surgery, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan; Corresponding author. Department of Thoracic Surgery, Graduate School of Medicine, Osaka Metropolitan University, 1-4-3 Asahi-machi, Abeno-ku, Osaka city, Osaka, Japan.A 71-year-old man was started on 12 mg/day of lenvatinib for lung metastasis from hepatocellular carcinoma (HCC). The day after starting treatment, he developed hemoptysis, and a CT scan revealed a rupture of the left upper lobe metastasis, accompanied by pulmonary hemorrhage. Angiography was performed, and the responsible blood vessels, the bronchial artery and the left pulmonary artery (A1+2ab), were embolized. One week later, the patient developed a left tension pneumothorax. Despite thoracic drainage, air leakage and bloody drainage persisted. We decided to perform a left upper lobe resection to control the bleeding and air leakage. A 10-cm necrotic lesion was found in the left upper lobe, and the pleura between the lobes had ruptured, causing a hematoma to drain into the pleural cavity. We encountered a case of hemopneumothorax resulting from the rupture of lung metastases from HCC during treatment with lenvatinib.http://www.sciencedirect.com/science/article/pii/S2213007125000693LenvatinibHemopneumothoraxLung metastasisHepatocellular carcinoma |
| spellingShingle | Kazuya Kishimoto Nobuhiro Izumi Hirotaka Kinoshita Takuya Tanimura Satoshi Suzuki Kantaro Hara Hidetoshi Inoue Takuma Tsukioka Masanori Shiohara Naoshi Odagiri Junichi Soh Pulmonary hemorrhage and hemopneumothorax following the administration of lenvatinib for lung metastasis from hepatocellular carcinoma Respiratory Medicine Case Reports Lenvatinib Hemopneumothorax Lung metastasis Hepatocellular carcinoma |
| title | Pulmonary hemorrhage and hemopneumothorax following the administration of lenvatinib for lung metastasis from hepatocellular carcinoma |
| title_full | Pulmonary hemorrhage and hemopneumothorax following the administration of lenvatinib for lung metastasis from hepatocellular carcinoma |
| title_fullStr | Pulmonary hemorrhage and hemopneumothorax following the administration of lenvatinib for lung metastasis from hepatocellular carcinoma |
| title_full_unstemmed | Pulmonary hemorrhage and hemopneumothorax following the administration of lenvatinib for lung metastasis from hepatocellular carcinoma |
| title_short | Pulmonary hemorrhage and hemopneumothorax following the administration of lenvatinib for lung metastasis from hepatocellular carcinoma |
| title_sort | pulmonary hemorrhage and hemopneumothorax following the administration of lenvatinib for lung metastasis from hepatocellular carcinoma |
| topic | Lenvatinib Hemopneumothorax Lung metastasis Hepatocellular carcinoma |
| url | http://www.sciencedirect.com/science/article/pii/S2213007125000693 |
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