Placental trophoblast aging in advanced maternal age is related to increased oxidative damage and decreased YAP

Placental trophoblast aging in advanced maternal age is related to increased oxidative damage and decreased YAP

IntroductionThe advanced maternal age (AMA) pregnancies escalate rapidly, which are frequently linked to higher risks of adverse outcomes. Advanced maternal age (AMA) placenta exhibited premature aging, presumably resulting in trophoblast dysfunction, inadequate placentation. However, the precise re...

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Bibliographic Details
Main Authors: Song Guo, Qihao Pan, Baokang Chen, Yijuan Huang, Si Li, Chenyu Gou, Yu Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
advanced maternal age
trophoblast aging
YAP
DNA oxidative damage
pregnancy complication
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1479960/full
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