Curcumin Improves Diabetic Cardiomyopathy by Inhibiting Pyroptosis through AKT/Nrf2/ARE Pathway

Curcumin Improves Diabetic Cardiomyopathy by Inhibiting Pyroptosis through AKT/Nrf2/ARE Pathway

This study is aimed at exploring whether curcumin can regulate the AKT pathway, promote the transfer of Nrf2 into the nucleus, and inhibit cell pyroptosis in diabetic cardiomyopathy. Diabetic rats and cardiomyocytes were treated with curcumin to study its effect on myocardial pyroptosis. Whether cur...

Full description

Saved in:

Bibliographic Details
Main Authors:	Zhang Wei, Kang pinfang, Zhou jing, Yao zhuoya, Qian Shaohuan, Shi Chao
Format:	Article
Language:	English
Published:	Wiley 2023-01-01
Series:	Mediators of Inflammation
Online Access:	http://dx.doi.org/10.1155/2023/3906043
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Quercetin Inhibits Pyroptosis in Diabetic Cardiomyopathy through the Nrf2 Pathway
by: Zhang Wei, et al.
Published: (2022-01-01)

Curcumin inhibits growth and triggers apoptosis in human castration-resistant prostate cancer cells via IGF-1/PI3K/Akt pathway
by: Chao Chen, et al.
Published: (2025-02-01)

Electroacupuncture combined with trigonelline inhibits pyroptosis in cerebral ischemia-reperfusion by suppressing autophagy via the PI3K/AKT/mTOR signaling pathway
by: Zhengguo Qiu, et al.
Published: (2025-02-01)

The Role of Quercetin and Exercise in Modulating Apoptosis and Cardiomyopathy via PI3K/AKT/FOXO3 Pathways in Diabetic Obese Rats
by: Mojdeh Khajehlandi, et al.
Published: (2024-09-01)

Hyaluronic acid-curcumin nanoparticles for preventing the progression of experimental autoimmune uveitis through the Keap1/Nrf2/HO-1 signaling pathway
by: Weiwei Tang, et al.
Published: (2025-02-01)

Curcumin Protects Neonatal Rat Cardiomyocytes against High Glucose-Induced Apoptosis via PI3K/Akt Signalling Pathway
by: Wei Yu, et al.
Published: (2016-01-01)

The Effects of Six Weeks of Endurance Training and CGRP Inhibition on Nrf2 and AKT Expression in the Hippocampal Tissue of Male Wistar Rats
by: Maryam Zare, et al.
Published: (2022-01-01)

Glucose Fluctuation Inhibits Nrf2 Signaling Pathway in Hippocampal Tissues and Exacerbates Cognitive Impairment in Streptozotocin-Induced Diabetic Rats
by: Haiyan Chi, et al.
Published: (2024-01-01)

Knockdown of Fibromodulin Inhibits Proliferation and Migration of RPE Cell via the VEGFR2-AKT Pathway
by: He Hu, et al.
Published: (2018-01-01)

CD137 Signaling Promotes Endothelial Apoptosis by Inhibiting Nrf2 Pathway, and Upregulating NF-κB Pathway
by: Tianxin Geng, et al.
Published: (2020-01-01)

HDAC Inhibition Modulates Cardiac PPARs and Fatty Acid Metabolism in Diabetic Cardiomyopathy
by: Ting-I Lee, et al.
Published: (2016-01-01)

Dapagliflozin inhibits ferroptosis to improve chronic heart failure by regulating Nrf2/HO-1/GPX4 signaling pathway.
by: Jing Zhang, et al.
Published: (2025-01-01)

Curcumin inhibits migration and invasion of non-small cell lung cancer cells through up-regulation of miR-206 and suppression of PI3K/AKT/mTOR signaling pathway
by: Wang Naizhi, et al.
Published: (2020-09-01)

Quercetin improves diabetic kidney disease by inhibiting ferroptosis and regulating the Nrf2 in streptozotocin-induced diabetic rats
by: Lei Zhang, et al.
Published: (2024-12-01)

The protective roles of eugenol on type 1 diabetes mellitus through NRF2-mediated oxidative stress pathway
by: Yalan Jiang, et al.
Published: (2025-01-01)

Beta-Hydroxybutyric Acid Inhibits Renal Tubular Reabsorption via the AKT/DAB2/Megalin Signalling Pathway
by: Minxia Zuo, et al.
Published: (2022-01-01)

Metallothionein 1B attenuates inflammation and hepatic steatosis in MASH by inhibiting the AKT/PI3K pathway
by: Canghai Guan, et al.
Published: (2025-01-01)

Yunvjian decoction attenuates lipopolysaccharide-induced acute lung injury by inhibiting NF-κB/NLRP3 pathway and pyroptosis
by: Fanxuan Zhang, et al.
Published: (2025-01-01)

Tangeretin alleviates sepsis-induced acute lung injury by inhibiting ferroptosis of macrophage via Nrf2 signaling pathway
by: Hui Zhang, et al.
Published: (2025-01-01)

Scutellarin inhibits pyroptosis via selective autophagy degradation of p30/GSDMD and suppression of ASC oligomerization
by: Danyue Li, et al.
Published: (2025-02-01)

Modified Gegen Qinlian Decoction Ameliorates DSS-Induced Ulcerative Colitis in Mice by Inhibiting Ferroptosis via Nrf2/GPX4 Pathway
by: Jinke Huang, et al.
Published: (2024-01-01)

Inhibition of Synovial Macrophage Pyroptosis Alleviates Synovitis and Fibrosis in Knee Osteoarthritis
by: Li Zhang, et al.
Published: (2019-01-01)

Wogonin Inhibits Cardiac Hypertrophy by Activating Nrf-2-Mediated Antioxidant Responses
by: Xiaowen Shi, et al.
Published: (2021-01-01)

The Protective Effect of Beraprost Sodium on Diabetic Cardiomyopathy through the Inhibition of the p38 MAPK Signaling Pathway in High-Fat-Induced SD Rats
by: Jie Li, et al.
Published: (2014-01-01)

Jingui Shenqi Wan alleviates bone loss induced by primary osteoporosis by inhibiting osteoblast pyroptosis
by: Yuwangxuan Qian, et al.
Published: (2025-02-01)

ERK1/2 Inhibition Alleviates Diabetic Cardiomyopathy by Suppressing Fatty Acid Metabolism
by: Erin McLean, et al.
Published: (2025-01-01)

Ursodeoxycholic acid protects against sepsis-induced acute kidney injury by activating Nrf2/HO-1 and inhibiting NF-κB pathway
by: Yunpeng Lou, et al.
Published: (2025-01-01)

Lonicera caerulea polyphenols inhibit fat absorption by regulating Nrf2-ARE pathway mediated epithelial barrier dysfunction and special microbiota
by: Yuehua Wang, et al.
Published: (2023-07-01)

Supramolecular prodrug inspiried by the Rhizoma Coptidis-Fructus Mume herbal pair alleviated inflammatory diseases by inhibiting pyroptosis
by: Wenhui Qian, et al.
Published: (2025-02-01)

Curcumin and α/β-Adrenergic Antagonists Cotreatment Reverse Liver Cirrhosis in Hamsters: Participation of Nrf-2 and NF-κB
by: José Roberto Macías-Pérez, et al.
Published: (2019-01-01)

The Nrf2/Keap1/ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus
by: Joshua A. David, et al.
Published: (2017-01-01)

PTEN suppresses renal cell carcinoma proliferation and migration via inhibition of the PI3K/AKT pathway
by: Xu Xu, et al.
Published: (2025-02-01)

Targeted inhibition of the PTEN/PI3K/AKT pathway by YSV induces cell cycle arrest and apoptosis in oral squamous cell carcinoma
by: Lin Qiu, et al.
Published: (2025-02-01)

Exendin-4 Protects against Hyperglycemia-Induced Cardiomyocyte Pyroptosis via the AMPK-TXNIP Pathway
by: Hong Wei, et al.
Published: (2019-01-01)

Severe Inflammation Caused by Coinfection of PCV2 and Glaesserella parasuis Is Associated with Pyroptosis via Noncanonical Inflammasome Pathway
by: Jiahui An, et al.
Published: (2022-01-01)

Zinc Supplementation Prevented Type 2 Diabetes-Induced Liver Injury Mediated by the Nrf2-MT Antioxidative Pathway
by: Lechu Yu, et al.
Published: (2021-01-01)

Inhibition of high glucose-induced cardiac fibroblast activation: an effective treatment for diabetic cardiomyopathy using Chinese herbal medicine
by: Bin Wan, et al.
Published: (2025-01-01)

HSF1 Alleviates Brain Injury by Inhibiting NLRP3-Induced Pyroptosis in a Sepsis Model
by: Yi-fu He, et al.
Published: (2023-01-01)

Targeting the Interplay Between Autophagy and the Nrf2 Pathway in Parkinson’s Disease with Potential Therapeutic Implications
by: Mengru Liu, et al.
Published: (2025-01-01)

The effect of AKT inhibition in α-synuclein-dependent neurodegeneration
by: Bedri Ranxhi, et al.
Published: (2025-02-01)