Clinical and biochemical characteristics for patients with polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes syndrome: a pilot observational study
BackgroundPolyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome is rare life-threatening condition associated with a clonal plasma cell neoplasm.ObjectiveThe aim of this study is to investigate the clinical and biochemical features in patients with POEMS syndrome...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1528376/full |
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| author | Pei Li Ye Zhang Li-Min Luo Wen-Qing Wang Jing Li Yan Cheng Xiao Dang Yang Chen Wei Jiang |
| author_facet | Pei Li Ye Zhang Li-Min Luo Wen-Qing Wang Jing Li Yan Cheng Xiao Dang Yang Chen Wei Jiang |
| author_sort | Pei Li |
| collection | DOAJ |
| description | BackgroundPolyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome is rare life-threatening condition associated with a clonal plasma cell neoplasm.ObjectiveThe aim of this study is to investigate the clinical and biochemical features in patients with POEMS syndrome before and post-therapy.MethodsCharacteristics of demographic information, underlying diseases, clinical manifestations, laboratory indicators, and imaging examination were retrospectively collected when diagnosed and post-therapy in the patients POEMS syndrome between 2018 and 2024.ResultsNineteen newly-diagnosed, treatment-naïve patients with POEMS syndrome were enrolled. The diagnosis of POEMS syndrome was re-analyzed and matched the diagnostic criteria updated in 2023. All patients presented the symptoms of polyneuropathy and positive for M-protein. Most patients suffered with hyperpigmentation (n = 18), organomegaly (n = 18), elevated vascular endothelial growth factor (VEGF) (n = 17), extravascular volume overload (n = 15), sclerotic bone lesions (n = 11), and hypothyroidism (n = 10). Serum alanine aminotransferase, aspartate aminotransferase, total bilirubin, total protein, and albumin levels were down-regulated, while uric acid level was up-regulated in patients with POEMS syndrome. Reduced triiodothyronine, thyroxine, free triiodothyronine levels were negatively correlated with urea nitrogen, creatinine, and uric acid levels in patients with POEMS syndrome. VEGF level, which was negatively correlated with Ca2+ level (r = −0.56), was reduced in most patients with POEMS syndrome receiving bortezomib/ixazomib and lenalidomide/thalidomide therapy. Aspartate aminotransferase, total protein, and estimated glomerular filtration rate levels were increased, while creatinine and uric acid levels were reduced post-therapy in patients with POEMS syndrome.ConclusionPatients with POEMS syndrome had impaired liver and renal function, and effective therapy might partly repair the liver and renal dysfunction. |
| format | Article |
| id | doaj-art-e012151ad8594504bbb31495b9324e4f |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-e012151ad8594504bbb31495b9324e4f2025-02-04T05:28:12ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-02-011610.3389/fneur.2025.15283761528376Clinical and biochemical characteristics for patients with polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes syndrome: a pilot observational studyPei Li0Ye Zhang1Li-Min Luo2Wen-Qing Wang3Jing Li4Yan Cheng5Xiao Dang6Yang Chen7Wei Jiang8Department of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, ChinaDepartment of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, ChinaDepartment of Infectious Diseases, Air Force Hospital of Southern Theatre Command, Guangzhou, Guangdong, ChinaDepartment of Hematology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, ChinaDepartment of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, ChinaDepartment of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, ChinaDepartment of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, ChinaSchool of Basic Medicine, Fourth Military Medical University, Xi'an, Shaanxi, ChinaDepartment of Nursing Affairs, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, ChinaBackgroundPolyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome is rare life-threatening condition associated with a clonal plasma cell neoplasm.ObjectiveThe aim of this study is to investigate the clinical and biochemical features in patients with POEMS syndrome before and post-therapy.MethodsCharacteristics of demographic information, underlying diseases, clinical manifestations, laboratory indicators, and imaging examination were retrospectively collected when diagnosed and post-therapy in the patients POEMS syndrome between 2018 and 2024.ResultsNineteen newly-diagnosed, treatment-naïve patients with POEMS syndrome were enrolled. The diagnosis of POEMS syndrome was re-analyzed and matched the diagnostic criteria updated in 2023. All patients presented the symptoms of polyneuropathy and positive for M-protein. Most patients suffered with hyperpigmentation (n = 18), organomegaly (n = 18), elevated vascular endothelial growth factor (VEGF) (n = 17), extravascular volume overload (n = 15), sclerotic bone lesions (n = 11), and hypothyroidism (n = 10). Serum alanine aminotransferase, aspartate aminotransferase, total bilirubin, total protein, and albumin levels were down-regulated, while uric acid level was up-regulated in patients with POEMS syndrome. Reduced triiodothyronine, thyroxine, free triiodothyronine levels were negatively correlated with urea nitrogen, creatinine, and uric acid levels in patients with POEMS syndrome. VEGF level, which was negatively correlated with Ca2+ level (r = −0.56), was reduced in most patients with POEMS syndrome receiving bortezomib/ixazomib and lenalidomide/thalidomide therapy. Aspartate aminotransferase, total protein, and estimated glomerular filtration rate levels were increased, while creatinine and uric acid levels were reduced post-therapy in patients with POEMS syndrome.ConclusionPatients with POEMS syndrome had impaired liver and renal function, and effective therapy might partly repair the liver and renal dysfunction.https://www.frontiersin.org/articles/10.3389/fneur.2025.1528376/fullPOEMS syndromeclinical characteristicsbiochemical indicatorsdiagnosistherapy |
| spellingShingle | Pei Li Ye Zhang Li-Min Luo Wen-Qing Wang Jing Li Yan Cheng Xiao Dang Yang Chen Wei Jiang Clinical and biochemical characteristics for patients with polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes syndrome: a pilot observational study Frontiers in Neurology POEMS syndrome clinical characteristics biochemical indicators diagnosis therapy |
| title | Clinical and biochemical characteristics for patients with polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes syndrome: a pilot observational study |
| title_full | Clinical and biochemical characteristics for patients with polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes syndrome: a pilot observational study |
| title_fullStr | Clinical and biochemical characteristics for patients with polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes syndrome: a pilot observational study |
| title_full_unstemmed | Clinical and biochemical characteristics for patients with polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes syndrome: a pilot observational study |
| title_short | Clinical and biochemical characteristics for patients with polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes syndrome: a pilot observational study |
| title_sort | clinical and biochemical characteristics for patients with polyneuropathy organomegaly endocrinopathy m protein and skin changes syndrome a pilot observational study |
| topic | POEMS syndrome clinical characteristics biochemical indicators diagnosis therapy |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1528376/full |
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