Advances in Pure Drug Self-Assembled Nanosystems: A Novel Strategy for Combined Cancer Therapy
Nanoparticle-based drug delivery systems hold great promise for improving the effectiveness of anti-tumor therapies. However, their clinical translation remains hindered by several significant challenges, including intricate preparation processes, limited drug loading capacity, and concerns regardin...
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| Format: | Article |
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MDPI AG
2025-01-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/17/1/68 |
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| author | Runyan Niu Xuexue Liu Xian Yang Xiao Du Siliang Wang Xiaolong Ma Shaoping Yin Lihua Shao Jinping Zhang |
| author_facet | Runyan Niu Xuexue Liu Xian Yang Xiao Du Siliang Wang Xiaolong Ma Shaoping Yin Lihua Shao Jinping Zhang |
| author_sort | Runyan Niu |
| collection | DOAJ |
| description | Nanoparticle-based drug delivery systems hold great promise for improving the effectiveness of anti-tumor therapies. However, their clinical translation remains hindered by several significant challenges, including intricate preparation processes, limited drug loading capacity, and concerns regarding potential toxicity. In this context, pure drug-assembled nanosystems (PDANSs) have emerged as a promising alternative, attracting extensive research interest due to their simple preparation methods, high drug loading efficiency, and suitability for large-scale industrial production. This innovative approach presents new opportunities to enhance both the safety and therapeutic efficacy of cancer treatments. This review comprehensively explores recent progress in the application of PDANSs for cancer therapy. It begins by detailing the self-assembly mechanisms and fundamental principles underlying PDANS formation. The discussion then advances to strategies for assembling single pure drug nanoparticles, as well as the co-assembly of multiple drugs. Subsequently, the review addresses the therapeutic potential of PDANSs in combination treatment modalities, encompassing diagnostic and therapeutic applications. These include combinations of chemotherapeutic agents, phototherapeutic approaches, the integration of chemotherapy with phototherapy, and the synergistic use of immunotherapy with other treatment methods. Finally, the review highlights the potential of PDANSs in advancing tumor therapy and their prospects for clinical application, providing key insights for future research aimed at optimizing this technology and broadening its utility in cancer treatment. |
| format | Article |
| id | doaj-art-e00cc557adeb4e3e933fe9be5147814e |
| institution | Kabale University |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-e00cc557adeb4e3e933fe9be5147814e2025-01-24T13:45:48ZengMDPI AGPharmaceutics1999-49232025-01-011716810.3390/pharmaceutics17010068Advances in Pure Drug Self-Assembled Nanosystems: A Novel Strategy for Combined Cancer TherapyRunyan Niu0Xuexue Liu1Xian Yang2Xiao Du3Siliang Wang4Xiaolong Ma5Shaoping Yin6Lihua Shao7Jinping Zhang8Nanjing Medical Center for Clinical Pharmacy, Department of Pharmacy, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, ChinaDepartment of Hematology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing 210008, ChinaNanjing Medical Center for Clinical Pharmacy, Department of Pharmacy, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, ChinaNanjing Medical Center for Clinical Pharmacy, Department of Pharmacy, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, ChinaNanjing Medical Center for Clinical Pharmacy, Department of Pharmacy, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, ChinaDepartment of Colorectal Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, ChinaSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210008, ChinaDepartment of Colorectal Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, ChinaNanjing Medical Center for Clinical Pharmacy, Department of Pharmacy, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, ChinaNanoparticle-based drug delivery systems hold great promise for improving the effectiveness of anti-tumor therapies. However, their clinical translation remains hindered by several significant challenges, including intricate preparation processes, limited drug loading capacity, and concerns regarding potential toxicity. In this context, pure drug-assembled nanosystems (PDANSs) have emerged as a promising alternative, attracting extensive research interest due to their simple preparation methods, high drug loading efficiency, and suitability for large-scale industrial production. This innovative approach presents new opportunities to enhance both the safety and therapeutic efficacy of cancer treatments. This review comprehensively explores recent progress in the application of PDANSs for cancer therapy. It begins by detailing the self-assembly mechanisms and fundamental principles underlying PDANS formation. The discussion then advances to strategies for assembling single pure drug nanoparticles, as well as the co-assembly of multiple drugs. Subsequently, the review addresses the therapeutic potential of PDANSs in combination treatment modalities, encompassing diagnostic and therapeutic applications. These include combinations of chemotherapeutic agents, phototherapeutic approaches, the integration of chemotherapy with phototherapy, and the synergistic use of immunotherapy with other treatment methods. Finally, the review highlights the potential of PDANSs in advancing tumor therapy and their prospects for clinical application, providing key insights for future research aimed at optimizing this technology and broadening its utility in cancer treatment.https://www.mdpi.com/1999-4923/17/1/68nanosystemsself-assemblycarrier-freecombination treatmentcancer therapypure drug |
| spellingShingle | Runyan Niu Xuexue Liu Xian Yang Xiao Du Siliang Wang Xiaolong Ma Shaoping Yin Lihua Shao Jinping Zhang Advances in Pure Drug Self-Assembled Nanosystems: A Novel Strategy for Combined Cancer Therapy Pharmaceutics nanosystems self-assembly carrier-free combination treatment cancer therapy pure drug |
| title | Advances in Pure Drug Self-Assembled Nanosystems: A Novel Strategy for Combined Cancer Therapy |
| title_full | Advances in Pure Drug Self-Assembled Nanosystems: A Novel Strategy for Combined Cancer Therapy |
| title_fullStr | Advances in Pure Drug Self-Assembled Nanosystems: A Novel Strategy for Combined Cancer Therapy |
| title_full_unstemmed | Advances in Pure Drug Self-Assembled Nanosystems: A Novel Strategy for Combined Cancer Therapy |
| title_short | Advances in Pure Drug Self-Assembled Nanosystems: A Novel Strategy for Combined Cancer Therapy |
| title_sort | advances in pure drug self assembled nanosystems a novel strategy for combined cancer therapy |
| topic | nanosystems self-assembly carrier-free combination treatment cancer therapy pure drug |
| url | https://www.mdpi.com/1999-4923/17/1/68 |
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