Four-Color Pseudovirus-Based Neutralization Assay: A Rapid Method for Evaluating Neutralizing Antibodies Against Quadrivalent Hand, Foot, and Mouth Disease Vaccine

Four-Color Pseudovirus-Based Neutralization Assay: A Rapid Method for Evaluating Neutralizing Antibodies Against Quadrivalent Hand, Foot, and Mouth Disease Vaccine

Background/Objectives: Enterovirus 71 (EV71) and coxsackieviruses A16 (CA16), A10 (CA10), and A6 (CA6) are the primary pathogens that cause hand, foot, and mouth disease (HFMD). Currently, many manufacturers are developing bivalent, trivalent, and tetravalent vaccines that target these antigens. Cel...

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Bibliographic Details
Main Authors: Fan Gao, Lingjie Xu, Qian Wang, Gang Wang, Mingchen Liu, Lu Li, Qian He, Xuanxuan Zhang, Ying Wang, Qunying Mao, Zhenglun Liang, Tao Wang, Xiao Ma, Xing Wu
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Vaccines
Subjects:
hand, foot, and mouth disease
enterovirus
quadrivalent vaccine
pseudovirus-based neutralization assay
Online Access:https://www.mdpi.com/2076-393X/13/3/320
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