Mendelian randomization analysis of the causal relationship between trimethylamine N-oxide and its precursors and Parkinson’s disease
Introduction Previous studies have reported a potential association between trimethylamine N-oxide (TMAO) and Parkinson’s disease (PD). The objective of this study was to examine the potential relationship between the levels of circulating TMAO and its precursors and the risk of PD using a two-sampl...
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Termedia Publishing House
2024-12-01
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| Series: | Archives of Medical Science |
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| author | Bei Zhang Ruijie Zhang Huiming Ren Qiongfeng Guan Weinv Fan Liyuan Han |
| author_facet | Bei Zhang Ruijie Zhang Huiming Ren Qiongfeng Guan Weinv Fan Liyuan Han |
| author_sort | Bei Zhang |
| collection | DOAJ |
| description | Introduction
Previous studies have reported a potential association between trimethylamine N-oxide (TMAO) and Parkinson’s disease (PD). The objective of this study was to examine the potential relationship between the levels of circulating TMAO and its precursors and the risk of PD using a two-sample Mendelian randomization (MR) approach.
Material and methods
We aggregated data from three genome-wide association studies (International Parkinson’s Disease Genomics Consortium, Parkinson’s Research: The Organized Genetics Initiative and GenePD, and FinnGen) to extract single-nucleotide polymorphisms (SNPs) associated with circulating concentrations of TMAO, choline, carnitine, and betaine. These SNPs were employed as instrumental variables in a random-effects model to evaluate the causal relationship between circulating concentrations of TMAO and its precursors and the risk of Parkinson’s disease, by estimating odds ratios with accompanying 95% confidence intervals. The primary analysis employed the inverse variance-weighted (IVW) method, which was complemented with MR-Egger regression analysis.
Results
The analysis using the IVW method, which aggregated data from the three databases, did not show any causal relationship between circulating concentrations of TMAO and its precursors, and the risk of PD (p > 0.05). This finding was further confirmed by the results of the MR-Egger analysis. A sensitivity analysis demonstrated that the results were not influenced by any biases, and a heterogeneity test indicated no significant variation among the SNPs.
Conclusions
This study did not identify any conclusive evidence of a causal association between the circulating concentrations of TMAO or its precursors and the risk of PD. Further investigation is warranted to determine whether such an association indeed exists. |
| format | Article |
| id | doaj-art-e00be14ec5734f768f5fb51b4962cb0c |
| institution | Kabale University |
| issn | 1734-1922 1896-9151 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj-art-e00be14ec5734f768f5fb51b4962cb0c2025-01-27T10:45:12ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512024-12-012061985199210.5114/aoms/184128184128Mendelian randomization analysis of the causal relationship between trimethylamine N-oxide and its precursors and Parkinson’s diseaseBei Zhang0Ruijie Zhang1Huiming Ren2Qiongfeng Guan3Weinv Fan4Liyuan Han5Center for Cardiovascular and Cerebrovascular Epidemiology and Translational Medicine, Ningbo Institute of Life and Health Industry, University of Chinese Academy of Sciences, Ningbo, ChinaKey Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, Ningbo No. 2 Hospital, Ningbo, ChinaDepartment of Rehabilitation Medicine, Ningbo No. 2 Hospital, Ningbo, ChinaDepartment of Neurology, Ningbo No. 2 Hospital, Ningbo, ChinaDepartment of Neurology, Ningbo No. 2 Hospital, Ningbo, ChinaDepartment of Global Health, Institute of Life and Health Industry, University of Chinese Academy of Sciences, Zhejiang, ChinaIntroduction Previous studies have reported a potential association between trimethylamine N-oxide (TMAO) and Parkinson’s disease (PD). The objective of this study was to examine the potential relationship between the levels of circulating TMAO and its precursors and the risk of PD using a two-sample Mendelian randomization (MR) approach. Material and methods We aggregated data from three genome-wide association studies (International Parkinson’s Disease Genomics Consortium, Parkinson’s Research: The Organized Genetics Initiative and GenePD, and FinnGen) to extract single-nucleotide polymorphisms (SNPs) associated with circulating concentrations of TMAO, choline, carnitine, and betaine. These SNPs were employed as instrumental variables in a random-effects model to evaluate the causal relationship between circulating concentrations of TMAO and its precursors and the risk of Parkinson’s disease, by estimating odds ratios with accompanying 95% confidence intervals. The primary analysis employed the inverse variance-weighted (IVW) method, which was complemented with MR-Egger regression analysis. Results The analysis using the IVW method, which aggregated data from the three databases, did not show any causal relationship between circulating concentrations of TMAO and its precursors, and the risk of PD (p > 0.05). This finding was further confirmed by the results of the MR-Egger analysis. A sensitivity analysis demonstrated that the results were not influenced by any biases, and a heterogeneity test indicated no significant variation among the SNPs. Conclusions This study did not identify any conclusive evidence of a causal association between the circulating concentrations of TMAO or its precursors and the risk of PD. Further investigation is warranted to determine whether such an association indeed exists.https://www.archivesofmedicalscience.com/Mendelian-randomization-analysis-of-the-causal-relationship-between-trimethylamine,184128,0,2.htmlparkinson’s diseasetrimethylamine n-oxidemendelian randomization |
| spellingShingle | Bei Zhang Ruijie Zhang Huiming Ren Qiongfeng Guan Weinv Fan Liyuan Han Mendelian randomization analysis of the causal relationship between trimethylamine N-oxide and its precursors and Parkinson’s disease Archives of Medical Science parkinson’s disease trimethylamine n-oxide mendelian randomization |
| title | Mendelian randomization analysis of the causal relationship between trimethylamine N-oxide and its precursors and Parkinson’s disease |
| title_full | Mendelian randomization analysis of the causal relationship between trimethylamine N-oxide and its precursors and Parkinson’s disease |
| title_fullStr | Mendelian randomization analysis of the causal relationship between trimethylamine N-oxide and its precursors and Parkinson’s disease |
| title_full_unstemmed | Mendelian randomization analysis of the causal relationship between trimethylamine N-oxide and its precursors and Parkinson’s disease |
| title_short | Mendelian randomization analysis of the causal relationship between trimethylamine N-oxide and its precursors and Parkinson’s disease |
| title_sort | mendelian randomization analysis of the causal relationship between trimethylamine n oxide and its precursors and parkinson s disease |
| topic | parkinson’s disease trimethylamine n-oxide mendelian randomization |
| url | https://www.archivesofmedicalscience.com/Mendelian-randomization-analysis-of-the-causal-relationship-between-trimethylamine,184128,0,2.html |
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