Establishing the Exposure‐QT Relationship During Bedaquiline Treatment Using a Time‐Varying Tuberculosis‐Specific Correction Factor (QTcTBT)

Establishing the Exposure‐QT Relationship During Bedaquiline Treatment Using a Time‐Varying Tuberculosis‐Specific Correction Factor (QTcTBT)

ABSTRACT Evaluating QT prolongation induced by anti‐tuberculosis (TB) drugs in patients with active TB, who often experience tachycardia, is challenging due to the limitations of Fridericia's correction factor (QTcF) in decorrelating QTc from heart rate (HR). Previous exposure‐QTcF analyses in...

Full description

Saved in:
Bibliographic Details
Main Authors: Thanakorn Vongjarudech, Anne‐Gaëlle Dosne, Bart Remmerie, Mats O. Karlsson, Elin M. Svensson
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:CPT: Pharmacometrics & Systems Pharmacology
Online Access:https://doi.org/10.1002/psp4.70047
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items