Impact of Dyslipidemia on Tear Film and Meibomian Gland Dysfunction: A Cross-Sectional Study of the Interplay between Serum Lipid Profile and Ocular Surface Health
Purpose. To determine the relationship between dyslipidemia and dry eye disease (DED), as well as its influence on tear film and meibomian glands. Methods. This cross-sectional study included 40 patients with a mean age of 35.2 ± 13.9 years without any history of dyslipidemia. DED and serum lipid pr...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2024/7345270 |
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| author | José-Manuel Serrano-Morales Noelia Álvarez-Santaliestra María Carmen Sánchez-González Antonio Ballesteros-Sánchez José-María Sánchez-González |
| author_facet | José-Manuel Serrano-Morales Noelia Álvarez-Santaliestra María Carmen Sánchez-González Antonio Ballesteros-Sánchez José-María Sánchez-González |
| author_sort | José-Manuel Serrano-Morales |
| collection | DOAJ |
| description | Purpose. To determine the relationship between dyslipidemia and dry eye disease (DED), as well as its influence on tear film and meibomian glands. Methods. This cross-sectional study included 40 patients with a mean age of 35.2 ± 13.9 years without any history of dyslipidemia. DED and serum lipid profile were evaluated after 8 hours of fasting. Patients were classified according to serum lipid levels with the following cut-off values: total cholesterol (TC) (200 mg/dl), high-density lipoprotein (HDL) (40 mg/dl), low-density lipoprotein (LDL) (130 mg/dl), and triglycerides (TG) (150 mg/dl). The relationship between serum lipid levels and DED was analyzed with the following variables: dry eye questionnaire-5 (DEQ-5), first (F-NIBUT) and average (A-NIBUT) noninvasive breakup time, tear meniscus height (TMH), lipid layer grade (LLG), conjunctival bulbar redness (CBR), and upper (U-LAMG) and lower (L-LAMG) loss area of meibomian glands. Results. Regarding tear film, patients with elevated TC and LDL levels reported significantly higher DEQ-5 scores and TMH (P<0.05), while those with lower HDL levels showed significantly higher LLG (p<0.05). Regarding MGD, patients with elevated TC, LDL, and TG, as well as lower HDL levels showed significantly higher L-LAMG (p<0.05). HDL was correlated with LLG (p<0.05), while TC was correlated with TMH (p<0.05) and L-LAMG (p<0.05), respectively. Conclusions. Disorders in TC, HDL, LDL, and TG levels were associated with DED, having an impact on the tear film and meibomian glands, specifically in DEQ-5 scores, LLG, and L-LAMG. |
| format | Article |
| id | doaj-art-e00a024d8374424c9a401beadbad5d3e |
| institution | OA Journals |
| issn | 2090-0058 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-e00a024d8374424c9a401beadbad5d3e2025-08-20T02:21:07ZengWileyJournal of Ophthalmology2090-00582024-01-01202410.1155/2024/7345270Impact of Dyslipidemia on Tear Film and Meibomian Gland Dysfunction: A Cross-Sectional Study of the Interplay between Serum Lipid Profile and Ocular Surface HealthJosé-Manuel Serrano-Morales0Noelia Álvarez-Santaliestra1María Carmen Sánchez-González2Antonio Ballesteros-Sánchez3José-María Sánchez-González4Department of Physics of Condensed MatterDepartment of Physics of Condensed MatterDepartment of Physics of Condensed MatterDepartment of Physics of Condensed MatterDepartment of Physics of Condensed MatterPurpose. To determine the relationship between dyslipidemia and dry eye disease (DED), as well as its influence on tear film and meibomian glands. Methods. This cross-sectional study included 40 patients with a mean age of 35.2 ± 13.9 years without any history of dyslipidemia. DED and serum lipid profile were evaluated after 8 hours of fasting. Patients were classified according to serum lipid levels with the following cut-off values: total cholesterol (TC) (200 mg/dl), high-density lipoprotein (HDL) (40 mg/dl), low-density lipoprotein (LDL) (130 mg/dl), and triglycerides (TG) (150 mg/dl). The relationship between serum lipid levels and DED was analyzed with the following variables: dry eye questionnaire-5 (DEQ-5), first (F-NIBUT) and average (A-NIBUT) noninvasive breakup time, tear meniscus height (TMH), lipid layer grade (LLG), conjunctival bulbar redness (CBR), and upper (U-LAMG) and lower (L-LAMG) loss area of meibomian glands. Results. Regarding tear film, patients with elevated TC and LDL levels reported significantly higher DEQ-5 scores and TMH (P<0.05), while those with lower HDL levels showed significantly higher LLG (p<0.05). Regarding MGD, patients with elevated TC, LDL, and TG, as well as lower HDL levels showed significantly higher L-LAMG (p<0.05). HDL was correlated with LLG (p<0.05), while TC was correlated with TMH (p<0.05) and L-LAMG (p<0.05), respectively. Conclusions. Disorders in TC, HDL, LDL, and TG levels were associated with DED, having an impact on the tear film and meibomian glands, specifically in DEQ-5 scores, LLG, and L-LAMG.http://dx.doi.org/10.1155/2024/7345270 |
| spellingShingle | José-Manuel Serrano-Morales Noelia Álvarez-Santaliestra María Carmen Sánchez-González Antonio Ballesteros-Sánchez José-María Sánchez-González Impact of Dyslipidemia on Tear Film and Meibomian Gland Dysfunction: A Cross-Sectional Study of the Interplay between Serum Lipid Profile and Ocular Surface Health Journal of Ophthalmology |
| title | Impact of Dyslipidemia on Tear Film and Meibomian Gland Dysfunction: A Cross-Sectional Study of the Interplay between Serum Lipid Profile and Ocular Surface Health |
| title_full | Impact of Dyslipidemia on Tear Film and Meibomian Gland Dysfunction: A Cross-Sectional Study of the Interplay between Serum Lipid Profile and Ocular Surface Health |
| title_fullStr | Impact of Dyslipidemia on Tear Film and Meibomian Gland Dysfunction: A Cross-Sectional Study of the Interplay between Serum Lipid Profile and Ocular Surface Health |
| title_full_unstemmed | Impact of Dyslipidemia on Tear Film and Meibomian Gland Dysfunction: A Cross-Sectional Study of the Interplay between Serum Lipid Profile and Ocular Surface Health |
| title_short | Impact of Dyslipidemia on Tear Film and Meibomian Gland Dysfunction: A Cross-Sectional Study of the Interplay between Serum Lipid Profile and Ocular Surface Health |
| title_sort | impact of dyslipidemia on tear film and meibomian gland dysfunction a cross sectional study of the interplay between serum lipid profile and ocular surface health |
| url | http://dx.doi.org/10.1155/2024/7345270 |
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