The in-vitro antimicrobial activity of some medicinal plants against β-lactam-resistant bacteria

Background: In effort to identify novel bacterial agents, this study was initiated to evaluate the antimicrobial properties of 17 crude extracts from 12 medicinal plants against beta-lactam-resistant bacteria. Methodology: The antimicrobial activities of plant extracts were evaluated against clin...

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Main Authors: Joseph Gangoue-Pieboji, Noelly Eze, Arnaud Ngongang Djintchui, Bathélémy Ngameni, Nolé Tsabang, Dieudonné Emmanuel Pegnyemb, Lucie Biyiti, Pierre Ngassam, Sinata Koulla-Shiro, Moreno Galleni
Format: Article
Language:English
Published: The Journal of Infection in Developing Countries 2009-10-01
Series:Journal of Infection in Developing Countries
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Online Access:https://jidc.org/index.php/journal/article/view/77
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author Joseph Gangoue-Pieboji
Noelly Eze
Arnaud Ngongang Djintchui
Bathélémy Ngameni
Nolé Tsabang
Dieudonné Emmanuel Pegnyemb
Lucie Biyiti
Pierre Ngassam
Sinata Koulla-Shiro
Moreno Galleni
author_facet Joseph Gangoue-Pieboji
Noelly Eze
Arnaud Ngongang Djintchui
Bathélémy Ngameni
Nolé Tsabang
Dieudonné Emmanuel Pegnyemb
Lucie Biyiti
Pierre Ngassam
Sinata Koulla-Shiro
Moreno Galleni
author_sort Joseph Gangoue-Pieboji
collection DOAJ
description Background: In effort to identify novel bacterial agents, this study was initiated to evaluate the antimicrobial properties of 17 crude extracts from 12 medicinal plants against beta-lactam-resistant bacteria. Methodology: The antimicrobial activities of plant extracts were evaluated against clinically proved beta-lactam-resistant bacteria (Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, Serratia marcescens, Acinetobacter baumannii, Staphylococcus aureus and Enterococcus sp.) and reference strains of bacteria (Escherichia coli ATCC 35218, Enterobacter aerogenes ATCC 29751, E. aerogenes ATCC 13048, Pseudomonas aeruginosa ATCC 27853 and Enterococcus hirae ATCC 9790) by using disc-diffusion and agar-dilution assays. Results: The crude plant extracts demonstrated broad spectrum activity against all bacteria tested with inhibition zones in the range of 8-30 mm. The minimal inhibitory concentration (MIC) values of different plant extracts against the tested bacteria were found to range from ≤ 0.3 to ≥ 10 mg ml-1. The most active plant extracts were from Dortenia picta and Bridelia micrantha (MIC: 1.25-10 mg ml-1) on beta-lactam-resistant Gram-negative bacilli and the extracts from B. micrantha, Mallotus oppositifolius, Garcinia lucida, Garcinia. kola, Campylospermum densiflorum (leaves) and C. zenkeri (root) on beta-lactam-resistant Gram-positive cocci (MIC: ≤ 0.3-5 mg ml-1). Conclusion: Of the 17 plant extracts studied, seven showed good antimicrobial activity against the tested bacteria. The stem bark of B. micrantha and the leaves of D. picta were most active towards beta-lactamase producing Gram-negative bacilli. This study shows that medicinal plants could be sources of compounds which can be used to fight against beta-lactam resistant bacteria.
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spelling doaj-art-e006bfcdac5d45aa98b0773504f0eae52025-08-20T02:57:45ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802009-10-0130910.3855/jidc.77The in-vitro antimicrobial activity of some medicinal plants against β-lactam-resistant bacteriaJoseph Gangoue-Pieboji0Noelly Eze1Arnaud Ngongang Djintchui2Bathélémy Ngameni3Nolé Tsabang4Dieudonné Emmanuel Pegnyemb5Lucie Biyiti6Pierre Ngassam7Sinata Koulla-Shiro8Moreno Galleni9Centre for Proteins Engineering, University of Liège, Institute of Chemistry B6, Sart-Tilman, B 4000 LiègeLaboratory of General Biology, Faculty of Science, University of Yaoundé I, P.O. Box 812 YaoundéDepartment of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812 YaoundéDepartment of Pharmacy and Traditional Pharmacopoeia, Faculty of Medicine and Biomedical Science, University of Yaoundé I, P.O. Box 8664, YaoundéCentre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plant Studies, P.O. Box 8404, YaoundéDepartment of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812 Yaoundé, CameroonCentre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plant StudiesLaboratory of General Biology, Faculty of Science, University of Yaoundé I, P.O. Box 812 YaoundéDepartment of Microbiology, Parasitology, Hematology and infectious Diseases, Faculty of Medicine and Biomedical Science, University of Yaoundé I, P.O. Box 1364, YaoundéCentre for Proteins Engineering, University of Liège, Institute of Chemistry B6, Sart-Tilman, B 4000 Liège Background: In effort to identify novel bacterial agents, this study was initiated to evaluate the antimicrobial properties of 17 crude extracts from 12 medicinal plants against beta-lactam-resistant bacteria. Methodology: The antimicrobial activities of plant extracts were evaluated against clinically proved beta-lactam-resistant bacteria (Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, Serratia marcescens, Acinetobacter baumannii, Staphylococcus aureus and Enterococcus sp.) and reference strains of bacteria (Escherichia coli ATCC 35218, Enterobacter aerogenes ATCC 29751, E. aerogenes ATCC 13048, Pseudomonas aeruginosa ATCC 27853 and Enterococcus hirae ATCC 9790) by using disc-diffusion and agar-dilution assays. Results: The crude plant extracts demonstrated broad spectrum activity against all bacteria tested with inhibition zones in the range of 8-30 mm. The minimal inhibitory concentration (MIC) values of different plant extracts against the tested bacteria were found to range from ≤ 0.3 to ≥ 10 mg ml-1. The most active plant extracts were from Dortenia picta and Bridelia micrantha (MIC: 1.25-10 mg ml-1) on beta-lactam-resistant Gram-negative bacilli and the extracts from B. micrantha, Mallotus oppositifolius, Garcinia lucida, Garcinia. kola, Campylospermum densiflorum (leaves) and C. zenkeri (root) on beta-lactam-resistant Gram-positive cocci (MIC: ≤ 0.3-5 mg ml-1). Conclusion: Of the 17 plant extracts studied, seven showed good antimicrobial activity against the tested bacteria. The stem bark of B. micrantha and the leaves of D. picta were most active towards beta-lactamase producing Gram-negative bacilli. This study shows that medicinal plants could be sources of compounds which can be used to fight against beta-lactam resistant bacteria. https://jidc.org/index.php/journal/article/view/77β-lactam-resistant bacteriaantimicrobial activityCameroonMedicinal plantβ-lactamase
spellingShingle Joseph Gangoue-Pieboji
Noelly Eze
Arnaud Ngongang Djintchui
Bathélémy Ngameni
Nolé Tsabang
Dieudonné Emmanuel Pegnyemb
Lucie Biyiti
Pierre Ngassam
Sinata Koulla-Shiro
Moreno Galleni
The in-vitro antimicrobial activity of some medicinal plants against β-lactam-resistant bacteria
Journal of Infection in Developing Countries
β-lactam-resistant bacteria
antimicrobial activity
Cameroon
Medicinal plant
β-lactamase
title The in-vitro antimicrobial activity of some medicinal plants against β-lactam-resistant bacteria
title_full The in-vitro antimicrobial activity of some medicinal plants against β-lactam-resistant bacteria
title_fullStr The in-vitro antimicrobial activity of some medicinal plants against β-lactam-resistant bacteria
title_full_unstemmed The in-vitro antimicrobial activity of some medicinal plants against β-lactam-resistant bacteria
title_short The in-vitro antimicrobial activity of some medicinal plants against β-lactam-resistant bacteria
title_sort in vitro antimicrobial activity of some medicinal plants against β lactam resistant bacteria
topic β-lactam-resistant bacteria
antimicrobial activity
Cameroon
Medicinal plant
β-lactamase
url https://jidc.org/index.php/journal/article/view/77
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