Nuclear Alpha-Synuclein in Parkinson’s Disease and the Malignant Transformation in Melanoma
Interpretation: These findings support the nuclear localization of p-ASyn in skin cells and show that its presence decreases PD and almost disappears in the malignant transformation of melanocytes, redistributing to the cytoplasm and intercellular spaces. This confirms the association between PD and...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/nri/1119424 |
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| _version_ | 1849717665077133312 |
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| author | María E. Jimenez-Capdeville Erika Chi-Ahumada Francisco García-Ortega Juan Pablo Castanedo-Cazares Robert Norman Ildefonso Rodríguez-Leyva |
| author_facet | María E. Jimenez-Capdeville Erika Chi-Ahumada Francisco García-Ortega Juan Pablo Castanedo-Cazares Robert Norman Ildefonso Rodríguez-Leyva |
| author_sort | María E. Jimenez-Capdeville |
| collection | DOAJ |
| description | Interpretation: These findings support the nuclear localization of p-ASyn in skin cells and show that its presence decreases PD and almost disappears in the malignant transformation of melanocytes, redistributing to the cytoplasm and intercellular spaces. This confirms the association between PD and melanoma, providing crucial insights into the role of p-ASyn in both diseases. |
| format | Article |
| id | doaj-art-e000968e66ac47f694ad00a35d1e579e |
| institution | DOAJ |
| issn | 2090-1860 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-e000968e66ac47f694ad00a35d1e579e2025-08-20T03:12:35ZengWileyNeurology Research International2090-18602025-01-01202510.1155/nri/1119424Nuclear Alpha-Synuclein in Parkinson’s Disease and the Malignant Transformation in MelanomaMaría E. Jimenez-Capdeville0Erika Chi-Ahumada1Francisco García-Ortega2Juan Pablo Castanedo-Cazares3Robert Norman4Ildefonso Rodríguez-Leyva5Departamento de BioquímicaDepartamento de BioquímicaCoordinación Académica Región AltiplanoDepartamento de DermatologíaCenter for Geriatric DermatologyDepartamento de BioquímicaInterpretation: These findings support the nuclear localization of p-ASyn in skin cells and show that its presence decreases PD and almost disappears in the malignant transformation of melanocytes, redistributing to the cytoplasm and intercellular spaces. This confirms the association between PD and melanoma, providing crucial insights into the role of p-ASyn in both diseases.http://dx.doi.org/10.1155/nri/1119424 |
| spellingShingle | María E. Jimenez-Capdeville Erika Chi-Ahumada Francisco García-Ortega Juan Pablo Castanedo-Cazares Robert Norman Ildefonso Rodríguez-Leyva Nuclear Alpha-Synuclein in Parkinson’s Disease and the Malignant Transformation in Melanoma Neurology Research International |
| title | Nuclear Alpha-Synuclein in Parkinson’s Disease and the Malignant Transformation in Melanoma |
| title_full | Nuclear Alpha-Synuclein in Parkinson’s Disease and the Malignant Transformation in Melanoma |
| title_fullStr | Nuclear Alpha-Synuclein in Parkinson’s Disease and the Malignant Transformation in Melanoma |
| title_full_unstemmed | Nuclear Alpha-Synuclein in Parkinson’s Disease and the Malignant Transformation in Melanoma |
| title_short | Nuclear Alpha-Synuclein in Parkinson’s Disease and the Malignant Transformation in Melanoma |
| title_sort | nuclear alpha synuclein in parkinson s disease and the malignant transformation in melanoma |
| url | http://dx.doi.org/10.1155/nri/1119424 |
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