The Spectrum of Histopathological Lesions in Children Presenting with Steroid-Resistant Nephrotic Syndrome at a Single Center in Pakistan
Steroid-resistant nephrotic syndrome (SRNS) is a common problem in pediatric nephrology practice. There is currently little information in the literature on the spectrum of histopathologic lesions in children presenting with SRNS in Pakistan. This study was designed to determine the histopathologic...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/681802 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832551364393172992 |
|---|---|
| author | Muhammed Mubarak Javed I. Kazi Shaheera Shakeel Ali Lanewala Seema Hashmi |
| author_facet | Muhammed Mubarak Javed I. Kazi Shaheera Shakeel Ali Lanewala Seema Hashmi |
| author_sort | Muhammed Mubarak |
| collection | DOAJ |
| description | Steroid-resistant nephrotic syndrome (SRNS) is a common problem in pediatric nephrology practice. There is currently little information in the literature on the spectrum of histopathologic lesions in children presenting with SRNS in Pakistan. This study was designed to determine the histopathologic lesions in children presenting with SRNS at our center. The study was conducted at the Histopathology Department, Sindh Institute of Urology and Transplantation (SIUT) from January 2009 to August 2011. All children (≤16 years) presenting with SRNS, in whom renal biopsies were performed, were included. Their demographic, clinical, laboratory, and histopathological data were retrieved from files and original renal biopsy forms. The results were analyzed by SPSS version 10.0.
A total of 147 children were included. Of these, 91 (61.9%) were males and 56 (38.1%) females, with male-to-female ratio of 1.6 : 1. The mean age was 7.03 ± 4.0 years (range: 6 months–16 years). The histopathological lesions seen on renal biopsies comprised of focal segmental glomerulosclerosis (FSGS) (38.5%), followed by minimal change disease (MCD) (23.2%), IgM nephropathy (IgMN) (13.6%), idiopathic mesangial proliferative GN (10.2%), membranous GN (8.2%), and mesangiocapillary GN (4.8%). Our results indicate that FSGS is the predominant lesion in children with SRNS, followed by MCD and IgMN. |
| format | Article |
| id | doaj-art-e0008d6fa00644a6b283b39823fc3ea0 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-e0008d6fa00644a6b283b39823fc3ea02025-02-03T06:01:41ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/681802681802The Spectrum of Histopathological Lesions in Children Presenting with Steroid-Resistant Nephrotic Syndrome at a Single Center in PakistanMuhammed Mubarak0Javed I. Kazi1Shaheera Shakeel2Ali Lanewala3Seema Hashmi4Histopathology Department, Sindh Institute of Urology and Transplantation (SIUT), Karachi 74200, PakistanHistopathology Department, Sindh Institute of Urology and Transplantation (SIUT), Karachi 74200, PakistanHistopathology Department, Sindh Institute of Urology and Transplantation (SIUT), Karachi 74200, PakistanPediatric Nephrology Department, Sindh Institute of Urology and Transplantation (SIUT), Karachi 74200, PakistanPediatric Nephrology Department, Sindh Institute of Urology and Transplantation (SIUT), Karachi 74200, PakistanSteroid-resistant nephrotic syndrome (SRNS) is a common problem in pediatric nephrology practice. There is currently little information in the literature on the spectrum of histopathologic lesions in children presenting with SRNS in Pakistan. This study was designed to determine the histopathologic lesions in children presenting with SRNS at our center. The study was conducted at the Histopathology Department, Sindh Institute of Urology and Transplantation (SIUT) from January 2009 to August 2011. All children (≤16 years) presenting with SRNS, in whom renal biopsies were performed, were included. Their demographic, clinical, laboratory, and histopathological data were retrieved from files and original renal biopsy forms. The results were analyzed by SPSS version 10.0. A total of 147 children were included. Of these, 91 (61.9%) were males and 56 (38.1%) females, with male-to-female ratio of 1.6 : 1. The mean age was 7.03 ± 4.0 years (range: 6 months–16 years). The histopathological lesions seen on renal biopsies comprised of focal segmental glomerulosclerosis (FSGS) (38.5%), followed by minimal change disease (MCD) (23.2%), IgM nephropathy (IgMN) (13.6%), idiopathic mesangial proliferative GN (10.2%), membranous GN (8.2%), and mesangiocapillary GN (4.8%). Our results indicate that FSGS is the predominant lesion in children with SRNS, followed by MCD and IgMN.http://dx.doi.org/10.1100/2012/681802 |
| spellingShingle | Muhammed Mubarak Javed I. Kazi Shaheera Shakeel Ali Lanewala Seema Hashmi The Spectrum of Histopathological Lesions in Children Presenting with Steroid-Resistant Nephrotic Syndrome at a Single Center in Pakistan The Scientific World Journal |
| title | The Spectrum of Histopathological Lesions in Children Presenting with Steroid-Resistant Nephrotic Syndrome at a Single Center in Pakistan |
| title_full | The Spectrum of Histopathological Lesions in Children Presenting with Steroid-Resistant Nephrotic Syndrome at a Single Center in Pakistan |
| title_fullStr | The Spectrum of Histopathological Lesions in Children Presenting with Steroid-Resistant Nephrotic Syndrome at a Single Center in Pakistan |
| title_full_unstemmed | The Spectrum of Histopathological Lesions in Children Presenting with Steroid-Resistant Nephrotic Syndrome at a Single Center in Pakistan |
| title_short | The Spectrum of Histopathological Lesions in Children Presenting with Steroid-Resistant Nephrotic Syndrome at a Single Center in Pakistan |
| title_sort | spectrum of histopathological lesions in children presenting with steroid resistant nephrotic syndrome at a single center in pakistan |
| url | http://dx.doi.org/10.1100/2012/681802 |
| work_keys_str_mv | AT muhammedmubarak thespectrumofhistopathologicallesionsinchildrenpresentingwithsteroidresistantnephroticsyndromeatasinglecenterinpakistan AT javedikazi thespectrumofhistopathologicallesionsinchildrenpresentingwithsteroidresistantnephroticsyndromeatasinglecenterinpakistan AT shaheerashakeel thespectrumofhistopathologicallesionsinchildrenpresentingwithsteroidresistantnephroticsyndromeatasinglecenterinpakistan AT alilanewala thespectrumofhistopathologicallesionsinchildrenpresentingwithsteroidresistantnephroticsyndromeatasinglecenterinpakistan AT seemahashmi thespectrumofhistopathologicallesionsinchildrenpresentingwithsteroidresistantnephroticsyndromeatasinglecenterinpakistan AT muhammedmubarak spectrumofhistopathologicallesionsinchildrenpresentingwithsteroidresistantnephroticsyndromeatasinglecenterinpakistan AT javedikazi spectrumofhistopathologicallesionsinchildrenpresentingwithsteroidresistantnephroticsyndromeatasinglecenterinpakistan AT shaheerashakeel spectrumofhistopathologicallesionsinchildrenpresentingwithsteroidresistantnephroticsyndromeatasinglecenterinpakistan AT alilanewala spectrumofhistopathologicallesionsinchildrenpresentingwithsteroidresistantnephroticsyndromeatasinglecenterinpakistan AT seemahashmi spectrumofhistopathologicallesionsinchildrenpresentingwithsteroidresistantnephroticsyndromeatasinglecenterinpakistan |