Time evolution of piglet cerebral blood volume after resuscitation from hypoxic-ischemic insult
Abstract Neonatal hypoxic-ischemic encephalopathy (HIE) is a significant cause of neonatal mortality and developmental disabilities. It has been revealed that the temporal behavior of the cerebral blood volume (CBV) carries information on the degree of hypoxia-ischemia. CBV can be estimated by means...
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| Format: | Article |
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-11898-8 |
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| author | Manabu Machida Tsutomu Mitsuie Yasuhiro Nakao Yinmon Htun Aya Morimoto Uiko Hanaoka Yukihiko Konishi Kosuke Koyano Shinji Nakamura Takashi Kusaka |
| author_facet | Manabu Machida Tsutomu Mitsuie Yasuhiro Nakao Yinmon Htun Aya Morimoto Uiko Hanaoka Yukihiko Konishi Kosuke Koyano Shinji Nakamura Takashi Kusaka |
| author_sort | Manabu Machida |
| collection | DOAJ |
| description | Abstract Neonatal hypoxic-ischemic encephalopathy (HIE) is a significant cause of neonatal mortality and developmental disabilities. It has been revealed that the temporal behavior of the cerebral blood volume (CBV) carries information on the degree of hypoxia-ischemia. CBV can be estimated by means of near-infrared spectroscopy. The change of CBV after the insult is related to the change of CBV during the insult. In this paper, we consider a mathematical model which governs the time evolution of CBV after the insult. We show that the temporal behavior of CBV can be predicted with the Kalman filter which is based on the mathematical model. Finding a governing equation opens up possibilities for a more quantitative diagnosis of HIE. |
| format | Article |
| id | doaj-art-dffb1de13d6e48ef92c1f4ea57f7a9a1 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-dffb1de13d6e48ef92c1f4ea57f7a9a12025-08-20T03:04:25ZengNature PortfolioScientific Reports2045-23222025-07-011511810.1038/s41598-025-11898-8Time evolution of piglet cerebral blood volume after resuscitation from hypoxic-ischemic insultManabu Machida0Tsutomu Mitsuie1Yasuhiro Nakao2Yinmon Htun3Aya Morimoto4Uiko Hanaoka5Yukihiko Konishi6Kosuke Koyano7Shinji Nakamura8Takashi Kusaka9Department of Informatics, Faculty of Engineering, Kindai UniversityMedical Engineering Equipment Management Center, Kagawa University HospitalDepartment of Pediatrics, Faculty of Medicine, Kagawa UniversityDepartment of Pediatrics, Faculty of Medicine, Kagawa UniversityMaternal Perinatal Center, Kagawa UniversityDepartment of Perinatology and Gynecology, Faculty of Medicine, Kagawa UniversityDepartment of Education for Children with Special Needs, Kagawa UniversityMaternal Perinatal Center, Kagawa UniversityDepartment of Pediatrics, Faculty of Medicine, Kagawa UniversityDepartment of Pediatrics, Faculty of Medicine, Kagawa UniversityAbstract Neonatal hypoxic-ischemic encephalopathy (HIE) is a significant cause of neonatal mortality and developmental disabilities. It has been revealed that the temporal behavior of the cerebral blood volume (CBV) carries information on the degree of hypoxia-ischemia. CBV can be estimated by means of near-infrared spectroscopy. The change of CBV after the insult is related to the change of CBV during the insult. In this paper, we consider a mathematical model which governs the time evolution of CBV after the insult. We show that the temporal behavior of CBV can be predicted with the Kalman filter which is based on the mathematical model. Finding a governing equation opens up possibilities for a more quantitative diagnosis of HIE.https://doi.org/10.1038/s41598-025-11898-8 |
| spellingShingle | Manabu Machida Tsutomu Mitsuie Yasuhiro Nakao Yinmon Htun Aya Morimoto Uiko Hanaoka Yukihiko Konishi Kosuke Koyano Shinji Nakamura Takashi Kusaka Time evolution of piglet cerebral blood volume after resuscitation from hypoxic-ischemic insult Scientific Reports |
| title | Time evolution of piglet cerebral blood volume after resuscitation from hypoxic-ischemic insult |
| title_full | Time evolution of piglet cerebral blood volume after resuscitation from hypoxic-ischemic insult |
| title_fullStr | Time evolution of piglet cerebral blood volume after resuscitation from hypoxic-ischemic insult |
| title_full_unstemmed | Time evolution of piglet cerebral blood volume after resuscitation from hypoxic-ischemic insult |
| title_short | Time evolution of piglet cerebral blood volume after resuscitation from hypoxic-ischemic insult |
| title_sort | time evolution of piglet cerebral blood volume after resuscitation from hypoxic ischemic insult |
| url | https://doi.org/10.1038/s41598-025-11898-8 |
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