A single-center cross-sectional study on the clinical profile of pancytopenia and a novel scoring system for megaloblastic anemia
Background: Our study tries to identify the main culprits causing pancytopenia and its typical clinical presentation, along with the clinical and hematological profile of megaloblastic anemia (MGA)-induced pancytopenia, in a tertiary care hospital in western India. Methods: This observational cross-...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-01-01
|
| Series: | Apollo Medicine |
| Subjects: | |
| Online Access: | http://www.apollomedicine.org/article.asp?issn=0976-0016;year=2022;volume=19;issue=3;spage=157;epage=162;aulast=Rathwa |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832543394124005376 |
|---|---|
| author | Sanjaykumar Somsingbhai Rathwa Darshankumar Manubhai Raval Shashwat Mallik Shahin Khan |
| author_facet | Sanjaykumar Somsingbhai Rathwa Darshankumar Manubhai Raval Shashwat Mallik Shahin Khan |
| author_sort | Sanjaykumar Somsingbhai Rathwa |
| collection | DOAJ |
| description | Background: Our study tries to identify the main culprits causing pancytopenia and its typical clinical presentation, along with the clinical and hematological profile of megaloblastic anemia (MGA)-induced pancytopenia, in a tertiary care hospital in western India. Methods: This observational cross-sectional study was carried out on 50 patients diagnosed with pancytopenia in our hospital over 1 year (January 2019–January 2020). A scoring system is also described to distinguish cobalamin deficiency from other etiologies of pancytopenia. Results: MGA due to cobalamin deficiency was the leading cause of pancytopenia. The most frequently seen sign was whiteness, while the most typical symptoms were lethargy, malaise, and generalized weakness. Patients between 20 and 50 years of age were most often affected, with a male predominance being noticed. While blood counts revealed life-threatening anemia in most patients, the leukopenia and thrombocytopenia were not as severe. Conclusion: It was concluded that MGA due to dietary deficiency of Vitamin B12 is the most common etiology for pancytopenia in western India. Our scoring system could be used as an alternative to serum cobalamin tests to diagnose cobalamin deficiency, subject to confirmation in larger populations. |
| format | Article |
| id | doaj-art-dff24852cea74a6da9d14bfacdc71ee6 |
| institution | Kabale University |
| issn | 0976-0016 2213-3682 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Apollo Medicine |
| spelling | doaj-art-dff24852cea74a6da9d14bfacdc71ee62025-02-03T11:48:20ZengSAGE PublishingApollo Medicine0976-00162213-36822022-01-0119315716210.4103/am.am_58_22A single-center cross-sectional study on the clinical profile of pancytopenia and a novel scoring system for megaloblastic anemiaSanjaykumar Somsingbhai RathwaDarshankumar Manubhai RavalShashwat MallikShahin KhanBackground: Our study tries to identify the main culprits causing pancytopenia and its typical clinical presentation, along with the clinical and hematological profile of megaloblastic anemia (MGA)-induced pancytopenia, in a tertiary care hospital in western India. Methods: This observational cross-sectional study was carried out on 50 patients diagnosed with pancytopenia in our hospital over 1 year (January 2019–January 2020). A scoring system is also described to distinguish cobalamin deficiency from other etiologies of pancytopenia. Results: MGA due to cobalamin deficiency was the leading cause of pancytopenia. The most frequently seen sign was whiteness, while the most typical symptoms were lethargy, malaise, and generalized weakness. Patients between 20 and 50 years of age were most often affected, with a male predominance being noticed. While blood counts revealed life-threatening anemia in most patients, the leukopenia and thrombocytopenia were not as severe. Conclusion: It was concluded that MGA due to dietary deficiency of Vitamin B12 is the most common etiology for pancytopenia in western India. Our scoring system could be used as an alternative to serum cobalamin tests to diagnose cobalamin deficiency, subject to confirmation in larger populations.http://www.apollomedicine.org/article.asp?issn=0976-0016;year=2022;volume=19;issue=3;spage=157;epage=162;aulast=Rathwanovel scoringpancytopeniavegetarian dietvitamin b12 deficiency |
| spellingShingle | Sanjaykumar Somsingbhai Rathwa Darshankumar Manubhai Raval Shashwat Mallik Shahin Khan A single-center cross-sectional study on the clinical profile of pancytopenia and a novel scoring system for megaloblastic anemia Apollo Medicine novel scoring pancytopenia vegetarian diet vitamin b12 deficiency |
| title | A single-center cross-sectional study on the clinical profile of pancytopenia and a novel scoring system for megaloblastic anemia |
| title_full | A single-center cross-sectional study on the clinical profile of pancytopenia and a novel scoring system for megaloblastic anemia |
| title_fullStr | A single-center cross-sectional study on the clinical profile of pancytopenia and a novel scoring system for megaloblastic anemia |
| title_full_unstemmed | A single-center cross-sectional study on the clinical profile of pancytopenia and a novel scoring system for megaloblastic anemia |
| title_short | A single-center cross-sectional study on the clinical profile of pancytopenia and a novel scoring system for megaloblastic anemia |
| title_sort | single center cross sectional study on the clinical profile of pancytopenia and a novel scoring system for megaloblastic anemia |
| topic | novel scoring pancytopenia vegetarian diet vitamin b12 deficiency |
| url | http://www.apollomedicine.org/article.asp?issn=0976-0016;year=2022;volume=19;issue=3;spage=157;epage=162;aulast=Rathwa |
| work_keys_str_mv | AT sanjaykumarsomsingbhairathwa asinglecentercrosssectionalstudyontheclinicalprofileofpancytopeniaandanovelscoringsystemformegaloblasticanemia AT darshankumarmanubhairaval asinglecentercrosssectionalstudyontheclinicalprofileofpancytopeniaandanovelscoringsystemformegaloblasticanemia AT shashwatmallik asinglecentercrosssectionalstudyontheclinicalprofileofpancytopeniaandanovelscoringsystemformegaloblasticanemia AT shahinkhan asinglecentercrosssectionalstudyontheclinicalprofileofpancytopeniaandanovelscoringsystemformegaloblasticanemia AT sanjaykumarsomsingbhairathwa singlecentercrosssectionalstudyontheclinicalprofileofpancytopeniaandanovelscoringsystemformegaloblasticanemia AT darshankumarmanubhairaval singlecentercrosssectionalstudyontheclinicalprofileofpancytopeniaandanovelscoringsystemformegaloblasticanemia AT shashwatmallik singlecentercrosssectionalstudyontheclinicalprofileofpancytopeniaandanovelscoringsystemformegaloblasticanemia AT shahinkhan singlecentercrosssectionalstudyontheclinicalprofileofpancytopeniaandanovelscoringsystemformegaloblasticanemia |