Glioblastoma Multiforme in the Posterior Cranial Fossa in a Patient with Neurofibromatosis Type I
Patients with Neurofibromatosis type 1 (NF1) have an increased risk of developing neoplasms. The most common brain tumors, found in 15%–20% of NF1 patients, are hypothalamic-optic gliomas, followed by brainstem and cerebellar pilocytic astrocytomas. These tumors generally have a benign nature. NF1 p...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2009/757898 |
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| author | Marike L. D. Broekman Roelof Risselada JooYeon Engelen-Lee Wim G. M. Spliet Bon H. Verweij |
| author_facet | Marike L. D. Broekman Roelof Risselada JooYeon Engelen-Lee Wim G. M. Spliet Bon H. Verweij |
| author_sort | Marike L. D. Broekman |
| collection | DOAJ |
| description | Patients with Neurofibromatosis type 1 (NF1) have an increased risk of developing neoplasms. The most common brain tumors, found in 15%–20% of NF1 patients, are hypothalamic-optic gliomas, followed by brainstem and cerebellar pilocytic astrocytomas. These tumors generally have a benign nature. NF1 patients are predisposed to a 5-fold increased incidence of high-grade astrocytomas, which are usually located in supratentorial regions of the brain. We present an NF1 patient who developed a high-grade astrocytoma in the posterior fossa and discuss possible pathophysiological mechanisms. |
| format | Article |
| id | doaj-art-dfd8109fffdb40f6bcc9f6623ddaebca |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-dfd8109fffdb40f6bcc9f6623ddaebca2025-08-20T03:26:09ZengWileyCase Reports in Medicine1687-96271687-96352009-01-01200910.1155/2009/757898757898Glioblastoma Multiforme in the Posterior Cranial Fossa in a Patient with Neurofibromatosis Type IMarike L. D. Broekman0Roelof Risselada1JooYeon Engelen-Lee2Wim G. M. Spliet3Bon H. Verweij4Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3508 GA Utrecht, The NetherlandsDepartment of Medical Informatics, Erasmus University Medical Center, 3051 GE Rotterdam, The NetherlandsDepartment of Pathology, University Medical Center Utrecht, 3508 GA Utrecht, The NetherlandsDepartment of Pathology, University Medical Center Utrecht, 3508 GA Utrecht, The NetherlandsRudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3508 GA Utrecht, The NetherlandsPatients with Neurofibromatosis type 1 (NF1) have an increased risk of developing neoplasms. The most common brain tumors, found in 15%–20% of NF1 patients, are hypothalamic-optic gliomas, followed by brainstem and cerebellar pilocytic astrocytomas. These tumors generally have a benign nature. NF1 patients are predisposed to a 5-fold increased incidence of high-grade astrocytomas, which are usually located in supratentorial regions of the brain. We present an NF1 patient who developed a high-grade astrocytoma in the posterior fossa and discuss possible pathophysiological mechanisms.http://dx.doi.org/10.1155/2009/757898 |
| spellingShingle | Marike L. D. Broekman Roelof Risselada JooYeon Engelen-Lee Wim G. M. Spliet Bon H. Verweij Glioblastoma Multiforme in the Posterior Cranial Fossa in a Patient with Neurofibromatosis Type I Case Reports in Medicine |
| title | Glioblastoma Multiforme in the Posterior Cranial Fossa in a Patient with Neurofibromatosis Type I |
| title_full | Glioblastoma Multiforme in the Posterior Cranial Fossa in a Patient with Neurofibromatosis Type I |
| title_fullStr | Glioblastoma Multiforme in the Posterior Cranial Fossa in a Patient with Neurofibromatosis Type I |
| title_full_unstemmed | Glioblastoma Multiforme in the Posterior Cranial Fossa in a Patient with Neurofibromatosis Type I |
| title_short | Glioblastoma Multiforme in the Posterior Cranial Fossa in a Patient with Neurofibromatosis Type I |
| title_sort | glioblastoma multiforme in the posterior cranial fossa in a patient with neurofibromatosis type i |
| url | http://dx.doi.org/10.1155/2009/757898 |
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