Sex-specific effects of exogenous asparagine on colorectal tumor growth, 17β-estradiol levels, and aromatase

Sex-specific effects of exogenous asparagine on colorectal tumor growth, 17β-estradiol levels, and aromatase

Sex-related differences in asparagine metabolism are associated with cancer prognosis. However, the effect of exogenous asparagine on colorectal cancer (CRC) growth in men and women remains unclear. This study aims to understand the relationship between exogenous asparagine supplementation and 17β-e...

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Bibliographic Details
Main Authors: Oladimeji Aladelokun, Katherine Benitez, Yuying Wang, Abhishek Jain, Domenica Berardi, Georgio Maroun, Xinyi Shen, Jatin Roper, Joanna Gibson, Kaelyn Sumigray, Sajid A. Khan, Caroline H. Johnson
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Pharmacological Research
Subjects:
Gastrointestinal cancer- colorectal
Asparagine
Pre-clinical models
Estrogen signaling
Sex differences
Aromatase
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825001616
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http://www.sciencedirect.com/science/article/pii/S1043661825001616

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