Genetic analysis of ERBB4 gene in Chinese patients with amyotrophic lateral sclerosis: a single-center study and systematic review of published literature

BackgroundRare ERBB4 variants have been implicated in amyotrophic lateral sclerosis (ALS), but their prevalence and clinical significance remain poorly understood, particularly across different ethnic populations.MethodsWe performed genetic screening of ERBB4 in 1627 Chinese ALS patients using whole...

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Bibliographic Details
Main Authors:	Dongchao Shen, Xunzhe Yang, Di He, Kang Zhang, Shuangwu Liu, Xiaohan Sun, Jinyue Li, Zhengyi Cai, Mingsheng Liu, Xue Zhang, Qing Liu, Liying Cui
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-05-01
Series:	Frontiers in Aging Neuroscience
Subjects:	ERBB4 variants amyotrophic lateral sclerosis genetic screening ethnic differences disease modifiers
Online Access:	https://www.frontiersin.org/articles/10.3389/fnagi.2025.1584541/full
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Genetic analysis of ERBB4 gene in Chinese patients with amyotrophic lateral sclerosis: a single-center study and systematic review of published literature

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