Protective Effects of a Probiotic <i>Lacticaseibacillus paracasei</i> MSMC39-1 on Kidney Damage in Aged Mice: Functional Foods Potential
Kidney fibrosis and inflammation are significant contributors to the decline in renal function associated with aging. These processes are characterized by structural changes, such as glomerular sclerosis and interstitial fibrosis, which exacerbate kidney injury and inflammation in aged individuals....
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-05-01
|
| Series: | Foods |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2304-8158/14/11/1874 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850128768868286464 |
|---|---|
| author | Pol Sookpotarom Jirapat Namkaew Kaikwa Wuttisa Chantanapa Chantarangkul Praewpannarai Jamjuree Thiranut Jaroonwitchawan Malai Taweechotipatr |
| author_facet | Pol Sookpotarom Jirapat Namkaew Kaikwa Wuttisa Chantanapa Chantarangkul Praewpannarai Jamjuree Thiranut Jaroonwitchawan Malai Taweechotipatr |
| author_sort | Pol Sookpotarom |
| collection | DOAJ |
| description | Kidney fibrosis and inflammation are significant contributors to the decline in renal function associated with aging. These processes are characterized by structural changes, such as glomerular sclerosis and interstitial fibrosis, which exacerbate kidney injury and inflammation in aged individuals. Probiotics have gained increasing attention for their potential health-promoting effects. However, further investigation is required to fully understand the mechanisms underlying these benefits. We hypothesize that probiotics could ameliorate fibrosis through the immunomodulatory effects of probiotics and by improving kidney tissue inflammation. Sixteen-month-old aging mice were administered <i>Lacticaseibacillus paracasei</i> MSMC39-1 for four months compared to young mice (six-month-old) and aged mice (twenty-month-old). The research found that following the administration of probiotic MSMC39-1, there were significant improvements in kidney inflammation, as evidenced by reductions in pro-inflammatory cytokines, fibrosis, and inflammatory cells within the tissue. Moreover, the findings demonstrated that probiotic MSMC39-1 significantly normalized levels of malondialdehyde (MDA), and rescued antioxidant superoxide dismutase (SOD) and glutathione peroxidase (Gpx) in kidney tissue which was consistent with a low mitochondria biogenesis. Further investigations revealed that conditioned medium from MSMC39-1 rescued epithelial kidney cells with damage induced by high glucose. This research provides information and insights into the mechanisms underlying the beneficial health effects of probiotics, offering a deeper understanding of how these probiotics contribute to anti-aging processes in the kidney. |
| format | Article |
| id | doaj-art-dfcfa63f46f34c088d74f10887d11ed1 |
| institution | OA Journals |
| issn | 2304-8158 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj-art-dfcfa63f46f34c088d74f10887d11ed12025-08-20T02:33:11ZengMDPI AGFoods2304-81582025-05-011411187410.3390/foods14111874Protective Effects of a Probiotic <i>Lacticaseibacillus paracasei</i> MSMC39-1 on Kidney Damage in Aged Mice: Functional Foods PotentialPol Sookpotarom0Jirapat Namkaew1Kaikwa Wuttisa2Chantanapa Chantarangkul3Praewpannarai Jamjuree4Thiranut Jaroonwitchawan5Malai Taweechotipatr6Doctor of Medicine Program, Faculty of Medicine, Srinakharinwirot University, Bangkok 10110, ThailandFuturistic Science Research Center, School of Science, Walailak University, Thasala, Nakhon Si Thammarat 80160, ThailandCenter of Excellence in Probiotics, Srinakharinwirot University, Bangkok 10110, ThailandCenter of Excellence in Probiotics, Srinakharinwirot University, Bangkok 10110, ThailandCenter of Excellence in Probiotics, Srinakharinwirot University, Bangkok 10110, ThailandFuturistic Science Research Center, School of Science, Walailak University, Thasala, Nakhon Si Thammarat 80160, ThailandCenter of Excellence in Probiotics, Srinakharinwirot University, Bangkok 10110, ThailandKidney fibrosis and inflammation are significant contributors to the decline in renal function associated with aging. These processes are characterized by structural changes, such as glomerular sclerosis and interstitial fibrosis, which exacerbate kidney injury and inflammation in aged individuals. Probiotics have gained increasing attention for their potential health-promoting effects. However, further investigation is required to fully understand the mechanisms underlying these benefits. We hypothesize that probiotics could ameliorate fibrosis through the immunomodulatory effects of probiotics and by improving kidney tissue inflammation. Sixteen-month-old aging mice were administered <i>Lacticaseibacillus paracasei</i> MSMC39-1 for four months compared to young mice (six-month-old) and aged mice (twenty-month-old). The research found that following the administration of probiotic MSMC39-1, there were significant improvements in kidney inflammation, as evidenced by reductions in pro-inflammatory cytokines, fibrosis, and inflammatory cells within the tissue. Moreover, the findings demonstrated that probiotic MSMC39-1 significantly normalized levels of malondialdehyde (MDA), and rescued antioxidant superoxide dismutase (SOD) and glutathione peroxidase (Gpx) in kidney tissue which was consistent with a low mitochondria biogenesis. Further investigations revealed that conditioned medium from MSMC39-1 rescued epithelial kidney cells with damage induced by high glucose. This research provides information and insights into the mechanisms underlying the beneficial health effects of probiotics, offering a deeper understanding of how these probiotics contribute to anti-aging processes in the kidney.https://www.mdpi.com/2304-8158/14/11/1874agingchronic inflammationanti-inflammationantioxidantprobiotics |
| spellingShingle | Pol Sookpotarom Jirapat Namkaew Kaikwa Wuttisa Chantanapa Chantarangkul Praewpannarai Jamjuree Thiranut Jaroonwitchawan Malai Taweechotipatr Protective Effects of a Probiotic <i>Lacticaseibacillus paracasei</i> MSMC39-1 on Kidney Damage in Aged Mice: Functional Foods Potential Foods aging chronic inflammation anti-inflammation antioxidant probiotics |
| title | Protective Effects of a Probiotic <i>Lacticaseibacillus paracasei</i> MSMC39-1 on Kidney Damage in Aged Mice: Functional Foods Potential |
| title_full | Protective Effects of a Probiotic <i>Lacticaseibacillus paracasei</i> MSMC39-1 on Kidney Damage in Aged Mice: Functional Foods Potential |
| title_fullStr | Protective Effects of a Probiotic <i>Lacticaseibacillus paracasei</i> MSMC39-1 on Kidney Damage in Aged Mice: Functional Foods Potential |
| title_full_unstemmed | Protective Effects of a Probiotic <i>Lacticaseibacillus paracasei</i> MSMC39-1 on Kidney Damage in Aged Mice: Functional Foods Potential |
| title_short | Protective Effects of a Probiotic <i>Lacticaseibacillus paracasei</i> MSMC39-1 on Kidney Damage in Aged Mice: Functional Foods Potential |
| title_sort | protective effects of a probiotic i lacticaseibacillus paracasei i msmc39 1 on kidney damage in aged mice functional foods potential |
| topic | aging chronic inflammation anti-inflammation antioxidant probiotics |
| url | https://www.mdpi.com/2304-8158/14/11/1874 |
| work_keys_str_mv | AT polsookpotarom protectiveeffectsofaprobioticilacticaseibacillusparacaseiimsmc391onkidneydamageinagedmicefunctionalfoodspotential AT jirapatnamkaew protectiveeffectsofaprobioticilacticaseibacillusparacaseiimsmc391onkidneydamageinagedmicefunctionalfoodspotential AT kaikwawuttisa protectiveeffectsofaprobioticilacticaseibacillusparacaseiimsmc391onkidneydamageinagedmicefunctionalfoodspotential AT chantanapachantarangkul protectiveeffectsofaprobioticilacticaseibacillusparacaseiimsmc391onkidneydamageinagedmicefunctionalfoodspotential AT praewpannaraijamjuree protectiveeffectsofaprobioticilacticaseibacillusparacaseiimsmc391onkidneydamageinagedmicefunctionalfoodspotential AT thiranutjaroonwitchawan protectiveeffectsofaprobioticilacticaseibacillusparacaseiimsmc391onkidneydamageinagedmicefunctionalfoodspotential AT malaitaweechotipatr protectiveeffectsofaprobioticilacticaseibacillusparacaseiimsmc391onkidneydamageinagedmicefunctionalfoodspotential |