Embolic Stroke as the Initial Manifestation of Systemic Lupus Erythematosus
We present a case of a 21-year-old African-American female with no significant medical history, who presented to the emergency department with a one-week history of blurry and double vision. Ophthalmology evaluation revealed bilateral retinal artery occlusion. Further workup with imaging of the brai...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2015/373201 |
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| author | Reshma M. Khan Rajaie Namas Sachin Parikh Bernard Rubin |
| author_facet | Reshma M. Khan Rajaie Namas Sachin Parikh Bernard Rubin |
| author_sort | Reshma M. Khan |
| collection | DOAJ |
| description | We present a case of a 21-year-old African-American female with no significant medical history, who presented to the emergency department with a one-week history of blurry and double vision. Ophthalmology evaluation revealed bilateral retinal artery occlusion. Further workup with imaging of the brain was consistent with an ischemic stroke. Hereditary hypercoagulable workup was unremarkable and initial testing for antiphospholipid syndrome was positive. She underwent transesophageal echocardiogram (TEE), which showed severe mitral regurgitation and thickening of mitral valve leaflets consistent with Libman-Sacks endocarditis. Autoimmune workup was positive for IF-ANA, anti-RNP, and anti-Smith antibody. She fulfilled 4/11 of the ACR criteria and met 5 of the SLICC (Systemic Lupus International Collaborating Clinics) criteria for lupus (nonscaring alopecia, thrombocytopenia, positive ANA, and positive anti-Smith and positive anti-phospholipid antibodies). This case highlights the importance of early recognition of underlying connective tissue diseases and timely management of these diseases in young patients with no previous manifestations of diseases. |
| format | Article |
| id | doaj-art-dfcb68fc54bf4a1bb2f4c00cc9f03237 |
| institution | Kabale University |
| issn | 2090-6889 2090-6897 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-dfcb68fc54bf4a1bb2f4c00cc9f032372025-02-03T05:46:58ZengWileyCase Reports in Rheumatology2090-68892090-68972015-01-01201510.1155/2015/373201373201Embolic Stroke as the Initial Manifestation of Systemic Lupus ErythematosusReshma M. Khan0Rajaie Namas1Sachin Parikh2Bernard Rubin3Department of Internal Medicine, Division of Rheumatology, Henry Ford Hospital, Wayne State University, Detroit, MI 48202, USADepartment of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI 48109, USADepartment of Internal Medicine, Division of Cardiology, Henry Ford Hospital, Detroit, MI 48202, USADepartment of Internal Medicine, Division of Rheumatology, Henry Ford Hospital, Wayne State University, Detroit, MI 48202, USAWe present a case of a 21-year-old African-American female with no significant medical history, who presented to the emergency department with a one-week history of blurry and double vision. Ophthalmology evaluation revealed bilateral retinal artery occlusion. Further workup with imaging of the brain was consistent with an ischemic stroke. Hereditary hypercoagulable workup was unremarkable and initial testing for antiphospholipid syndrome was positive. She underwent transesophageal echocardiogram (TEE), which showed severe mitral regurgitation and thickening of mitral valve leaflets consistent with Libman-Sacks endocarditis. Autoimmune workup was positive for IF-ANA, anti-RNP, and anti-Smith antibody. She fulfilled 4/11 of the ACR criteria and met 5 of the SLICC (Systemic Lupus International Collaborating Clinics) criteria for lupus (nonscaring alopecia, thrombocytopenia, positive ANA, and positive anti-Smith and positive anti-phospholipid antibodies). This case highlights the importance of early recognition of underlying connective tissue diseases and timely management of these diseases in young patients with no previous manifestations of diseases.http://dx.doi.org/10.1155/2015/373201 |
| spellingShingle | Reshma M. Khan Rajaie Namas Sachin Parikh Bernard Rubin Embolic Stroke as the Initial Manifestation of Systemic Lupus Erythematosus Case Reports in Rheumatology |
| title | Embolic Stroke as the Initial Manifestation of Systemic Lupus Erythematosus |
| title_full | Embolic Stroke as the Initial Manifestation of Systemic Lupus Erythematosus |
| title_fullStr | Embolic Stroke as the Initial Manifestation of Systemic Lupus Erythematosus |
| title_full_unstemmed | Embolic Stroke as the Initial Manifestation of Systemic Lupus Erythematosus |
| title_short | Embolic Stroke as the Initial Manifestation of Systemic Lupus Erythematosus |
| title_sort | embolic stroke as the initial manifestation of systemic lupus erythematosus |
| url | http://dx.doi.org/10.1155/2015/373201 |
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