Genome-Wide Association Study of Liver Enzymes in Korean Children
Liver enzyme elevations, as an indicator of liver function, are widely associated with metabolic diseases. Genome-wide population-based association studies have identified a genetic susceptibility to liver enzyme elevations and their related traits; however, the genetic architecture in childhood rem...
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| Language: | English |
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BioMed Central
2013-09-01
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| Series: | Genomics & Informatics |
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| Online Access: | http://genominfo.org/upload/pdf/gni-11-149.pdf |
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| author | Tae-Joon Park Joo-Yeon Hwang Min Jin Go Hye-Ja Lee Han Byul Jang Youngshim Choi Jae Heon Kang Kyung Hee Park Min-Gyu Choi Jihyun Song Bong-Jo Kim Jong-Young Lee |
| author_facet | Tae-Joon Park Joo-Yeon Hwang Min Jin Go Hye-Ja Lee Han Byul Jang Youngshim Choi Jae Heon Kang Kyung Hee Park Min-Gyu Choi Jihyun Song Bong-Jo Kim Jong-Young Lee |
| author_sort | Tae-Joon Park |
| collection | DOAJ |
| description | Liver enzyme elevations, as an indicator of liver function, are widely associated with metabolic diseases. Genome-wide population-based association studies have identified a genetic susceptibility to liver enzyme elevations and their related traits; however, the genetic architecture in childhood remains largely unknown. We performed a genome-wide association study to identify new genetic loci for liver enzyme levels in a Korean childhood cohort (n = 484). We observed three novel loci (rs4949718, rs80311637, and rs596406) that were multiply associated with elevated levels of alanine transaminase and aspartate transaminase. Although there are some limitations, including genetic power, additional replication and functional characterization will support the clarity on the genetic contribution that the ST6GALNAC3, ADAMTS9, and CELF2 genes have in childhood liver function. |
| format | Article |
| id | doaj-art-dfc5abcb6be64248ad6ac6b374c43cfc |
| institution | Kabale University |
| issn | 1598-866X 2234-0742 |
| language | English |
| publishDate | 2013-09-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-dfc5abcb6be64248ad6ac6b374c43cfc2025-02-02T19:52:33ZengBioMed CentralGenomics & Informatics1598-866X2234-07422013-09-0111314915410.5808/GI.2013.11.3.14950Genome-Wide Association Study of Liver Enzymes in Korean ChildrenTae-Joon Park0Joo-Yeon Hwang1Min Jin Go2Hye-Ja Lee3Han Byul Jang4Youngshim Choi5Jae Heon Kang6Kyung Hee Park7Min-Gyu Choi8Jihyun Song9Bong-Jo Kim10Jong-Young Lee11Division of Structural and Functional Genomics, Center for Genome Science, Korea National Institute of Health, Cheongwon 363-951, Korea.Division of Structural and Functional Genomics, Center for Genome Science, Korea National Institute of Health, Cheongwon 363-951, Korea.Division of Structural and Functional Genomics, Center for Genome Science, Korea National Institute of Health, Cheongwon 363-951, Korea.Division of Metabolic Diseases, Center for Biomedical Sciences, Korea National Institute of Health, Cheongwon 363-951, Korea.Division of Metabolic Diseases, Center for Biomedical Sciences, Korea National Institute of Health, Cheongwon 363-951, Korea.Division of Metabolic Diseases, Center for Biomedical Sciences, Korea National Institute of Health, Cheongwon 363-951, Korea.Department of Family Medicine, Obesity Research Institute, Inje University Seoul Paik Hospital, Inje University College of Medicine, Seoul 100-032, Korea.Department of Family Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 431-796, Korea.Department of Family Medicine, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul 150-950, Korea.Division of Metabolic Diseases, Center for Biomedical Sciences, Korea National Institute of Health, Cheongwon 363-951, Korea.Division of Structural and Functional Genomics, Center for Genome Science, Korea National Institute of Health, Cheongwon 363-951, Korea.Ministry of Health and Welfare, Seoul 110-793, Korea.Liver enzyme elevations, as an indicator of liver function, are widely associated with metabolic diseases. Genome-wide population-based association studies have identified a genetic susceptibility to liver enzyme elevations and their related traits; however, the genetic architecture in childhood remains largely unknown. We performed a genome-wide association study to identify new genetic loci for liver enzyme levels in a Korean childhood cohort (n = 484). We observed three novel loci (rs4949718, rs80311637, and rs596406) that were multiply associated with elevated levels of alanine transaminase and aspartate transaminase. Although there are some limitations, including genetic power, additional replication and functional characterization will support the clarity on the genetic contribution that the ST6GALNAC3, ADAMTS9, and CELF2 genes have in childhood liver function.http://genominfo.org/upload/pdf/gni-11-149.pdfalanine transaminaseaspartate transaminasechildhood liver enzymegenome-wide association study |
| spellingShingle | Tae-Joon Park Joo-Yeon Hwang Min Jin Go Hye-Ja Lee Han Byul Jang Youngshim Choi Jae Heon Kang Kyung Hee Park Min-Gyu Choi Jihyun Song Bong-Jo Kim Jong-Young Lee Genome-Wide Association Study of Liver Enzymes in Korean Children Genomics & Informatics alanine transaminase aspartate transaminase childhood liver enzyme genome-wide association study |
| title | Genome-Wide Association Study of Liver Enzymes in Korean Children |
| title_full | Genome-Wide Association Study of Liver Enzymes in Korean Children |
| title_fullStr | Genome-Wide Association Study of Liver Enzymes in Korean Children |
| title_full_unstemmed | Genome-Wide Association Study of Liver Enzymes in Korean Children |
| title_short | Genome-Wide Association Study of Liver Enzymes in Korean Children |
| title_sort | genome wide association study of liver enzymes in korean children |
| topic | alanine transaminase aspartate transaminase childhood liver enzyme genome-wide association study |
| url | http://genominfo.org/upload/pdf/gni-11-149.pdf |
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