COVID-19 and APOL-1 High-Risk Genotype-Associated Collapsing Glomerulonephritis
Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily affects the lungs and can lead to acute respiratory distress syndrome (ARDS). The ongoing global pandemic has created healthcare and economic crisis for almost every nation of the wor...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2021/3737751 |
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| author | Sasmit Roy Srikanth Kunaparaju Narayana Murty Koduri Vikram Sangani Mytri Pokal Venu Madhav Konala Mamtha Balla Sreedhar Adapa |
| author_facet | Sasmit Roy Srikanth Kunaparaju Narayana Murty Koduri Vikram Sangani Mytri Pokal Venu Madhav Konala Mamtha Balla Sreedhar Adapa |
| author_sort | Sasmit Roy |
| collection | DOAJ |
| description | Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily affects the lungs and can lead to acute respiratory distress syndrome (ARDS). The ongoing global pandemic has created healthcare and economic crisis for almost every nation of the world. Though primarily affecting the lungs, it has also affected the kidney in various ways including acute kidney injury (AKI), proteinuria, and hematuria. It has been increasingly shown that African American (AA) individuals affected with COVID-19 and presenting with AKI and nephrotic-range proteinuria are very susceptible to focal segmental glomerulosclerosis (FSGS). The APOL-1 gene, associated with the African American population, has been increasingly recognized as a risk factor for FSGS affected with COVID-19. Our case highlights a similar case of COVID-19 in a 65-year-old AA descendant with biopsy-proven FSGS and genetically confirmed APOL-1 alleles. |
| format | Article |
| id | doaj-art-dfc123d572734d0cb9ef0d328c4ecab0 |
| institution | Kabale University |
| issn | 2090-6641 2090-665X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-dfc123d572734d0cb9ef0d328c4ecab02025-02-03T07:24:22ZengWileyCase Reports in Nephrology2090-66412090-665X2021-01-01202110.1155/2021/37377513737751COVID-19 and APOL-1 High-Risk Genotype-Associated Collapsing GlomerulonephritisSasmit Roy0Srikanth Kunaparaju1Narayana Murty Koduri2Vikram Sangani3Mytri Pokal4Venu Madhav Konala5Mamtha Balla6Sreedhar Adapa7Lynchburg Nephrology Physicians, 2091 Langhorne Road, Lynchburg, VA 24501, USARichmond Nephrology Associates, 671 Hioaks Road, Suite B, Richmond, VA 23225, USAGreat Plains Health, 601 W Leota St, North Platte, NE 69101, USAQuantum HC, Department of Internal Medicine, Navicent Health, 777 Hemlock Street, Macon, GA 31201, USAQuantum HC, Department of Internal Medicine, Navicent Health, 777 Hemlock Street, Macon, GA 31201, USAPrecision Cancer Center, 122 St Christopher Dr, Ashland, KY 41101, USAPromedica Toledo Hospital, 2142 N Cove Blvd, Toledo, OH 43606, USAAdventist Medical Center, 115 Mall Drive, Hanford, CA 93230, USACoronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily affects the lungs and can lead to acute respiratory distress syndrome (ARDS). The ongoing global pandemic has created healthcare and economic crisis for almost every nation of the world. Though primarily affecting the lungs, it has also affected the kidney in various ways including acute kidney injury (AKI), proteinuria, and hematuria. It has been increasingly shown that African American (AA) individuals affected with COVID-19 and presenting with AKI and nephrotic-range proteinuria are very susceptible to focal segmental glomerulosclerosis (FSGS). The APOL-1 gene, associated with the African American population, has been increasingly recognized as a risk factor for FSGS affected with COVID-19. Our case highlights a similar case of COVID-19 in a 65-year-old AA descendant with biopsy-proven FSGS and genetically confirmed APOL-1 alleles.http://dx.doi.org/10.1155/2021/3737751 |
| spellingShingle | Sasmit Roy Srikanth Kunaparaju Narayana Murty Koduri Vikram Sangani Mytri Pokal Venu Madhav Konala Mamtha Balla Sreedhar Adapa COVID-19 and APOL-1 High-Risk Genotype-Associated Collapsing Glomerulonephritis Case Reports in Nephrology |
| title | COVID-19 and APOL-1 High-Risk Genotype-Associated Collapsing Glomerulonephritis |
| title_full | COVID-19 and APOL-1 High-Risk Genotype-Associated Collapsing Glomerulonephritis |
| title_fullStr | COVID-19 and APOL-1 High-Risk Genotype-Associated Collapsing Glomerulonephritis |
| title_full_unstemmed | COVID-19 and APOL-1 High-Risk Genotype-Associated Collapsing Glomerulonephritis |
| title_short | COVID-19 and APOL-1 High-Risk Genotype-Associated Collapsing Glomerulonephritis |
| title_sort | covid 19 and apol 1 high risk genotype associated collapsing glomerulonephritis |
| url | http://dx.doi.org/10.1155/2021/3737751 |
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