Pioglitazone Ameliorates Neuron Loss in the Cortex after Aluminum-Treatment in Rats
The objective was evaluation of the effects of pioglitazone on medial prefrontal cortex (mPFC) of the rats exposed to aluminum (Al). Al induces structural changes in several brain regions, including mPFC. Pioglitazone is an agonist of peroxisomal proliferator activated receptor gamma. Male rats were...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2015/381934 |
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| author | Ali Rafati Hajar Yazdani Ali Noorafshan |
| author_facet | Ali Rafati Hajar Yazdani Ali Noorafshan |
| author_sort | Ali Rafati |
| collection | DOAJ |
| description | The objective was evaluation of the effects of pioglitazone on medial prefrontal cortex (mPFC) of the rats exposed to aluminum (Al). Al induces structural changes in several brain regions, including mPFC. Pioglitazone is an agonist of peroxisomal proliferator activated receptor gamma. Male rats were randomly assigned to control, Al-treated (10 mg/kg/day), and Al + PIO-treated groups (Al+ 40 mg/kg/day). After 56 days, the right mPFCs were removed. Then, the volume of mPFC and its subdivisions, volume of vessels, and total number of neurons and glia were estimated using stereological methods. The results showed 13–38% decrease in the volume of the mPFC and its subdivisions, mainly in the infralimbic region (P<0.02). Besides, the volume of the vessels reduced by 47% after Al-treatment (P<0.02). The total number of the neurons and glial cells was also reduced (40% and 25%, resp.) in the Al-exposed rats in comparison to the control ones (P<0.02). Treatment of the animals with Al + PIO ameliorated the neuron loss and no improvement was seen in other parameters (P<0.02). It can be concluded that treatment of the rats with PIO could ameliorate the neuron loss in the mPFC of the Al-treated animals. |
| format | Article |
| id | doaj-art-dfbdb348c38f4a8595f0804762118fee |
| institution | Kabale University |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-dfbdb348c38f4a8595f0804762118fee2025-02-03T01:29:54ZengWileyNeurology Research International2090-18522090-18602015-01-01201510.1155/2015/381934381934Pioglitazone Ameliorates Neuron Loss in the Cortex after Aluminum-Treatment in RatsAli Rafati0Hajar Yazdani1Ali Noorafshan2Histomorphometry and Stereology Research Centre, Shiraz University of Medical Sciences, Shiraz, IranPhysiology Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranHistomorphometry and Stereology Research Centre, Shiraz University of Medical Sciences, Shiraz, IranThe objective was evaluation of the effects of pioglitazone on medial prefrontal cortex (mPFC) of the rats exposed to aluminum (Al). Al induces structural changes in several brain regions, including mPFC. Pioglitazone is an agonist of peroxisomal proliferator activated receptor gamma. Male rats were randomly assigned to control, Al-treated (10 mg/kg/day), and Al + PIO-treated groups (Al+ 40 mg/kg/day). After 56 days, the right mPFCs were removed. Then, the volume of mPFC and its subdivisions, volume of vessels, and total number of neurons and glia were estimated using stereological methods. The results showed 13–38% decrease in the volume of the mPFC and its subdivisions, mainly in the infralimbic region (P<0.02). Besides, the volume of the vessels reduced by 47% after Al-treatment (P<0.02). The total number of the neurons and glial cells was also reduced (40% and 25%, resp.) in the Al-exposed rats in comparison to the control ones (P<0.02). Treatment of the animals with Al + PIO ameliorated the neuron loss and no improvement was seen in other parameters (P<0.02). It can be concluded that treatment of the rats with PIO could ameliorate the neuron loss in the mPFC of the Al-treated animals.http://dx.doi.org/10.1155/2015/381934 |
| spellingShingle | Ali Rafati Hajar Yazdani Ali Noorafshan Pioglitazone Ameliorates Neuron Loss in the Cortex after Aluminum-Treatment in Rats Neurology Research International |
| title | Pioglitazone Ameliorates Neuron Loss in the Cortex after Aluminum-Treatment in Rats |
| title_full | Pioglitazone Ameliorates Neuron Loss in the Cortex after Aluminum-Treatment in Rats |
| title_fullStr | Pioglitazone Ameliorates Neuron Loss in the Cortex after Aluminum-Treatment in Rats |
| title_full_unstemmed | Pioglitazone Ameliorates Neuron Loss in the Cortex after Aluminum-Treatment in Rats |
| title_short | Pioglitazone Ameliorates Neuron Loss in the Cortex after Aluminum-Treatment in Rats |
| title_sort | pioglitazone ameliorates neuron loss in the cortex after aluminum treatment in rats |
| url | http://dx.doi.org/10.1155/2015/381934 |
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