Serum CXCL12 and S100A12 levels in peripheral blood fluid and their correlation with severity in patients with knee osteoarthritis
Background: This paper aimed to investigate the expression of CXCL12 and S100A12 in peripheral blood (PB) and synovial fluid (SF) of patients with knee osteoarthritis (OS) and to analyze the correlation between them and the severity of knee OS. Methods: Sixty patients with knee OS treated in our hos...
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Society of Medical Biochemists of Serbia, Belgrade
2025-01-01
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| Series: | Journal of Medical Biochemistry |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582501011T.pdf |
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| author | LijiangTao Minjuan He Yisheng Lu Jie Zheng Yili Ye |
| author_facet | LijiangTao Minjuan He Yisheng Lu Jie Zheng Yili Ye |
| author_sort | LijiangTao |
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| description | Background: This paper aimed to investigate the expression of CXCL12 and S100A12 in peripheral blood (PB) and synovial fluid (SF) of patients with knee osteoarthritis (OS) and to analyze the correlation between them and the severity of knee OS. Methods: Sixty patients with knee OS treated in our hospital from January 2020 to December 2022 were selected as the experimental group, and 60 healthy knee joints with similar ages were selected as the control group. The fasting venous blood of 120 subjects was drawn in the early morning, and the SF was extracted during joint operation or sodium hyaluronate injection. Put the collected PB and SF in the refrigerator at -80 °C. The levels of CXCL12 and S100A12 in PB and SF were detected by enzyme-linked immunosorbent assay (Elisa). Results: The correlation between the levels of CXCL12 and S100A12 in PB and SF and Kmurl L grade and WOMAC score. The levels of CXCL12 and S100A12 in PB and SF in the observation group were higher than those in the control group. There were significant differences in the levels of CXCL12 and S100A12 in PB and SF in the experimental group. The higher the Kmurl grade of knee OS, the higher the concentration of CXCL12 and S100A12 in PB and SF. The levels of CXCL12 and S100A12 in PB of knee OS were positively correlated with WOMAC score (r=0.767, 0.521, respectively, P<0.05); see Figure 1. The levels of CXCL12 and S100A12 in SF of knee OS were positively correlated with WOMAC score (r=0.663, 0.357 respectively, P<0.05). The levels of CXCL12 and S100A12 in PB and SF are positively correlated with the severity of knee OS. Conclusions: The levels of CXCL12 and S100A12 in PB and SF can provide the basis for the evaluation and prognosis of knee OS. |
| format | Article |
| id | doaj-art-dfb70f2e0396489d8e8f97251cdb4d5d |
| institution | Kabale University |
| issn | 1452-8258 1452-8266 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
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| series | Journal of Medical Biochemistry |
| spelling | doaj-art-dfb70f2e0396489d8e8f97251cdb4d5d2025-02-05T13:11:23ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662025-01-01441111610.5937/jomb0-463101452-82582501011TSerum CXCL12 and S100A12 levels in peripheral blood fluid and their correlation with severity in patients with knee osteoarthritisLijiangTao0Minjuan He1Yisheng Lu2Jie Zheng3Yili Ye4Zhejiang Provincial People's Hospital, Department of Orthopedics, Hangzhou, ChinaThe 903 Hospital of the Joint Service Support Department of the Chinese People's Liberation Army, Department of Orthopedics, Hangzhou, ChinaThe 903 Hospital of the Joint Service Support Department of the Chinese People's Liberation Army, Department of Orthopedics, Hangzhou, ChinaThe 903 Hospital of the Joint Service Support Department of the Chinese People's Liberation Army, Department of Orthopedics, Hangzhou, ChinaTaizhou Traditional Chinese Medicine Hospital (Currently in the Logistics Support Department), Department of Orthopedics, Taizhou, ChinaBackground: This paper aimed to investigate the expression of CXCL12 and S100A12 in peripheral blood (PB) and synovial fluid (SF) of patients with knee osteoarthritis (OS) and to analyze the correlation between them and the severity of knee OS. Methods: Sixty patients with knee OS treated in our hospital from January 2020 to December 2022 were selected as the experimental group, and 60 healthy knee joints with similar ages were selected as the control group. The fasting venous blood of 120 subjects was drawn in the early morning, and the SF was extracted during joint operation or sodium hyaluronate injection. Put the collected PB and SF in the refrigerator at -80 °C. The levels of CXCL12 and S100A12 in PB and SF were detected by enzyme-linked immunosorbent assay (Elisa). Results: The correlation between the levels of CXCL12 and S100A12 in PB and SF and Kmurl L grade and WOMAC score. The levels of CXCL12 and S100A12 in PB and SF in the observation group were higher than those in the control group. There were significant differences in the levels of CXCL12 and S100A12 in PB and SF in the experimental group. The higher the Kmurl grade of knee OS, the higher the concentration of CXCL12 and S100A12 in PB and SF. The levels of CXCL12 and S100A12 in PB of knee OS were positively correlated with WOMAC score (r=0.767, 0.521, respectively, P<0.05); see Figure 1. The levels of CXCL12 and S100A12 in SF of knee OS were positively correlated with WOMAC score (r=0.663, 0.357 respectively, P<0.05). The levels of CXCL12 and S100A12 in PB and SF are positively correlated with the severity of knee OS. Conclusions: The levels of CXCL12 and S100A12 in PB and SF can provide the basis for the evaluation and prognosis of knee OS.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582501011T.pdfknee osteoarthritiscxcl12s100a12correlation |
| spellingShingle | LijiangTao Minjuan He Yisheng Lu Jie Zheng Yili Ye Serum CXCL12 and S100A12 levels in peripheral blood fluid and their correlation with severity in patients with knee osteoarthritis Journal of Medical Biochemistry knee osteoarthritis cxcl12 s100a12 correlation |
| title | Serum CXCL12 and S100A12 levels in peripheral blood fluid and their correlation with severity in patients with knee osteoarthritis |
| title_full | Serum CXCL12 and S100A12 levels in peripheral blood fluid and their correlation with severity in patients with knee osteoarthritis |
| title_fullStr | Serum CXCL12 and S100A12 levels in peripheral blood fluid and their correlation with severity in patients with knee osteoarthritis |
| title_full_unstemmed | Serum CXCL12 and S100A12 levels in peripheral blood fluid and their correlation with severity in patients with knee osteoarthritis |
| title_short | Serum CXCL12 and S100A12 levels in peripheral blood fluid and their correlation with severity in patients with knee osteoarthritis |
| title_sort | serum cxcl12 and s100a12 levels in peripheral blood fluid and their correlation with severity in patients with knee osteoarthritis |
| topic | knee osteoarthritis cxcl12 s100a12 correlation |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582501011T.pdf |
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