Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function

Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function

Abstract Eukaryotic initiation factor 4E (eIF4E) serves as a regulatory hub for oncogene-driven protein synthesis and is considered a promising anticancer target. Here we screen a fragment library against eIF4E and identify a ligand-binding site with previously unknown function. Follow-up structure-...

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Main Authors: Swee Y. Sharp, Marianna Martella, Sabrina D’Agostino, Christopher I. Milton, George Ward, Andrew J. Woodhead, Caroline J. Richardson, Maria G. Carr, Elisabetta Chiarparin, Benjamin D. Cons, Joseph Coyle, Charlotte E. East, Steven D. Hiscock, Carlos Martinez-Fleites, Paul N. Mortenson, Nick Palmer, Puja Pathuri, Marissa V. Powers, Susanne M. Saalau, Jeffrey D. St. Denis, Kate Swabey, Mladen Vinković, Hugh Walton, Glyn Williams, Paul A. Clarke
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54356-1
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