FXR acts as a therapeutic target for ulcerative colitis via suppressing ferroptosis

FXR acts as a therapeutic target for ulcerative colitis via suppressing ferroptosis

Abstract Background The involvement of ferroptosis in ulcerative colitis (UC) is increasingly acknowledged. Several investigations have revealed the various mechanisms by which the farnesoid X receptor (FXR) inhibits ferroptosis in certain diseases; however, its potential modulation of ferroptosis i...

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Bibliographic Details
Main Authors: Chenye Zhao, Xiaopeng Li, Mingchao Mu, Liyong Quan, Hang Yuan, Jianbao Zheng, Wei Zhao, Xuejun Sun, Junhui Yu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Molecular Medicine
Subjects:
FXR
Colitis
Ferroptosis
SLC7A11
GPX4
OTUB1
Online Access:https://doi.org/10.1186/s10020-025-01305-3
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