EGb761 suppressed vascular dementia via modulating Wnt/β-catenin signaling pathway-induced apoptosis and autophagy in hippocampal neuronal cells

EGb761 suppressed vascular dementia via modulating Wnt/β-catenin signaling pathway-induced apoptosis and autophagy in hippocampal neuronal cells

Abstract Objectives The study aimed to explore the effects of EGb761 on vascular dementia (VD) rats and the mechanisms of action. Methods The Morris water maze test was utilized to assess the spatial learning and memory abilities of the rats; Hematoxylin and Eosin (HE) staining and electron microsco...

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Bibliographic Details
Main Authors: Nan Yin, Zhipeng Tang, Yanyan Yang, Xiuqin Li, Ruisheng Duan, Guodong Xu, Peiyuan Lv
Format: Article
Language:English
Published: BMC 2025-06-01
Series:European Journal of Medical Research
Subjects:
Vascular dementia rats
Hippocampal neurons
EGb761
Wnt/β-catenin signaling pathway
Autophagy
Online Access:https://doi.org/10.1186/s40001-025-02681-6
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