Chronic voluntary wheel running exercise ameliorates metabolic dysfunction via PGC-1α expression independently of FNDC5/irisin pathway in high fat diet-induced obese mice

Chronic voluntary wheel running exercise ameliorates metabolic dysfunction via PGC-1α expression independently of FNDC5/irisin pathway in high fat diet-induced obese mice

Abstract Exercise is an effective intervention to ameliorate metabolic diseases including obesity and insulin resistance, but the mechanisms involved in the metabolic amelioration have not yet been fully elucidated. This study aimed to determine whether AMPK–SIRT1–PGC-1α–FNDC5/Irisin-UCP1 expression...

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Bibliographic Details
Main Authors: Chaeeun Cho, Minje Ji, Eunhee Cho, Seon Yi, Jae Geun Kim, Sewon Lee
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Journal of Physiological Sciences
Subjects:
Exercise
Irisin
UCP1
PGC-1α
FNDC5
Online Access:https://doi.org/10.1186/s12576-023-00864-6
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