The influencing factors and prognosis analysis of positive initial margin in intraoperative frozen section during breast-conserving surgery
Abstract Objectives A critical measure to reduce the risk of ipsilateral breast tumor recurrence after breast-conserving surgery (BCS) for patients with early invasive breast cancer (BC) is ensuring negative margins through frozen section intraoperative margin assessment (FSIMA).This study aims to e...
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| Language: | English |
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BMC
2025-05-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-025-02631-2 |
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| author | Shanshan Yan Yongnan Wang Yingye Feng Yujuan Guo Huang Tang Hongyi Gao |
| author_facet | Shanshan Yan Yongnan Wang Yingye Feng Yujuan Guo Huang Tang Hongyi Gao |
| author_sort | Shanshan Yan |
| collection | DOAJ |
| description | Abstract Objectives A critical measure to reduce the risk of ipsilateral breast tumor recurrence after breast-conserving surgery (BCS) for patients with early invasive breast cancer (BC) is ensuring negative margins through frozen section intraoperative margin assessment (FSIMA).This study aims to evaluate the influencing factors and prognosis associated with positive initial margins in FSIMA. Methods The clinical data of 436 BC patients treated with BCS were retrospectively analyzed, and long-term follow-up outcomes were evaluated. Results Among the 436 patients, approximately 90.8% (396/436) underwent successful BCS, while 71.8% (313/436) exhibited initial negative margins based on FSIMA. A total of 123 patients (28.2%) had positive initial margins, following additional excisions in some cases, 89 patients achieved negative margins. Univariate and multivariate analyses revealed significant differences between the positive and negative margin groups in tumor diameter, distance from the tumor to the nipple, and axillary lymph node metastasis (P < 0.05). No significant differences were observed in disease-free survival or overall survival between the two groups (P > 0.05). Conclusions The findings suggest that tumor diameter, the distance between the tumor and nipple, and axillary lymph node metastasis may influence the determination of positive initial margins in FSIMA. Positive initial margins do not appear to influence disease-free survival (DFS) or overall survival (OS) among BC patients treated with BCS. |
| format | Article |
| id | doaj-art-df875d4b74de43cdb512475b56f9acb4 |
| institution | OA Journals |
| issn | 2047-783X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-df875d4b74de43cdb512475b56f9acb42025-08-20T01:51:28ZengBMCEuropean Journal of Medical Research2047-783X2025-05-013011810.1186/s40001-025-02631-2The influencing factors and prognosis analysis of positive initial margin in intraoperative frozen section during breast-conserving surgeryShanshan Yan0Yongnan Wang1Yingye Feng2Yujuan Guo3Huang Tang4Hongyi Gao5Department of Pathology, Guangdong Women and Children HospitalBreast Disease Center, Guangdong Women and Children HospitalDepartment of Pathology, Guangdong Women and Children HospitalDepartment of Pathology, Guangdong Women and Children HospitalBreast Disease Center, Guangdong Women and Children HospitalDepartment of Pathology, Guangdong Women and Children HospitalAbstract Objectives A critical measure to reduce the risk of ipsilateral breast tumor recurrence after breast-conserving surgery (BCS) for patients with early invasive breast cancer (BC) is ensuring negative margins through frozen section intraoperative margin assessment (FSIMA).This study aims to evaluate the influencing factors and prognosis associated with positive initial margins in FSIMA. Methods The clinical data of 436 BC patients treated with BCS were retrospectively analyzed, and long-term follow-up outcomes were evaluated. Results Among the 436 patients, approximately 90.8% (396/436) underwent successful BCS, while 71.8% (313/436) exhibited initial negative margins based on FSIMA. A total of 123 patients (28.2%) had positive initial margins, following additional excisions in some cases, 89 patients achieved negative margins. Univariate and multivariate analyses revealed significant differences between the positive and negative margin groups in tumor diameter, distance from the tumor to the nipple, and axillary lymph node metastasis (P < 0.05). No significant differences were observed in disease-free survival or overall survival between the two groups (P > 0.05). Conclusions The findings suggest that tumor diameter, the distance between the tumor and nipple, and axillary lymph node metastasis may influence the determination of positive initial margins in FSIMA. Positive initial margins do not appear to influence disease-free survival (DFS) or overall survival (OS) among BC patients treated with BCS.https://doi.org/10.1186/s40001-025-02631-2Breast-conserving therapyBreast cancerFrozen sectionMargin |
| spellingShingle | Shanshan Yan Yongnan Wang Yingye Feng Yujuan Guo Huang Tang Hongyi Gao The influencing factors and prognosis analysis of positive initial margin in intraoperative frozen section during breast-conserving surgery European Journal of Medical Research Breast-conserving therapy Breast cancer Frozen section Margin |
| title | The influencing factors and prognosis analysis of positive initial margin in intraoperative frozen section during breast-conserving surgery |
| title_full | The influencing factors and prognosis analysis of positive initial margin in intraoperative frozen section during breast-conserving surgery |
| title_fullStr | The influencing factors and prognosis analysis of positive initial margin in intraoperative frozen section during breast-conserving surgery |
| title_full_unstemmed | The influencing factors and prognosis analysis of positive initial margin in intraoperative frozen section during breast-conserving surgery |
| title_short | The influencing factors and prognosis analysis of positive initial margin in intraoperative frozen section during breast-conserving surgery |
| title_sort | influencing factors and prognosis analysis of positive initial margin in intraoperative frozen section during breast conserving surgery |
| topic | Breast-conserving therapy Breast cancer Frozen section Margin |
| url | https://doi.org/10.1186/s40001-025-02631-2 |
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