Reduced murine double minute-2 methylation from peripheral blood mononuclear cells correlates with enhanced oxidative stress in hepatitis b virus-related hepatocellular carcinoma

Reduced murine double minute-2 methylation from peripheral blood mononuclear cells correlates with enhanced oxidative stress in hepatitis b virus-related hepatocellular carcinoma

BackgroundHepatitis B virus-related hepatocarcinogenesis (HBV-related HCC) involves a variety of causes including oncogene hypomethylation, oxidative stress and HBV itself. Oxidative stress induces an alternation in the DNA methylation status. We aimed to study the relationship between oxidative str...

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Bibliographic Details
Main Authors: Jing-Wen Wang, Han-Xu Zhu, Feng Zhang, He Wang, Yu-Chen Fan, Li-Yan Han, Kai Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Microbiology
Subjects:
HBV-related hepatocellular carcinoma
murine double minute-2
oxidative stress
DNA methylation
metabolomics
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1590492/full
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