Shedding light on DNA methylation and its clinical implications: the impact of long-read-based nanopore technology

Shedding light on DNA methylation and its clinical implications: the impact of long-read-based nanopore technology

Abstract DNA methylation is an essential epigenetic mechanism for regulation of gene expression, through which many physiological (X-chromosome inactivation, genetic imprinting, chromatin structure and miRNA regulation, genome defense, silencing of transposable elements) and pathological processes (...

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Bibliographic Details
Main Authors: Alexandra Chera, Mircea Stancu-Cretu, Nicolae Radu Zabet, Octavian Bucur
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Epigenetics & Chromatin
Subjects:
Nanopore sequencing
Long-read sequencing
DNA methylation
Epigenomics
Methylome
Online Access:https://doi.org/10.1186/s13072-024-00558-2
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