SHMT2 Overexpression Predicts Poor Prognosis in Intrahepatic Cholangiocarcinoma
Background and Objective. Serine hydroxymethyltransferase 2 (SHMT2) functions as a key enzyme in serine/glycine biosynthesis and one-carbon metabolism. Recent studies have shown that SHMT2 participated in tumor growth and progression in a variety of cancer types. The objective of the present study i...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2018/4369253 |
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| author | Shanglei Ning Siquan Ma Abdul Qahar Saleh Lingyu Guo Zixiao Zhao Yuxin Chen |
| author_facet | Shanglei Ning Siquan Ma Abdul Qahar Saleh Lingyu Guo Zixiao Zhao Yuxin Chen |
| author_sort | Shanglei Ning |
| collection | DOAJ |
| description | Background and Objective. Serine hydroxymethyltransferase 2 (SHMT2) functions as a key enzyme in serine/glycine biosynthesis and one-carbon metabolism. Recent studies have shown that SHMT2 participated in tumor growth and progression in a variety of cancer types. The objective of the present study is to explore the expression of SHMT2 and evaluate its prognostic value in patients with intrahepatic cholangiocarcinoma (iCCA). Patients and Methods. We retrospectively investigated the expression of SHMT2 in 100 primary iCCA samples through immunohistochemical (IHC) staining on a tissue array. Results. High SHMT2 expression was found in 52 of the 100 specimens. The results indicated that SHMT2 level was upregulated compared to adjacent nontumor intrahepatic bile duct tissue. Furthermore, SHMT2 level was closely associated with tumor T stage (P=0.017) and tumor TNM stage (P=0.041) in patients with iCCA, but not with age, gender, tumor size, tumor number, pathological grade, vascular invasion, or N stage. Moreover, Kaplan-Meier analysis suggested that patients with lower SHMT2 level have longer survival rate than those with high expression (45.8 vs 23.1%, P=0.030). Additionally, the multivariate analysis model indicated SHMT2 is an independent adverse prognosticator in iCCA. Conclusion. High SHMT2 level was correlated with poorer overall survival in patients with iCCA. SHMT2 was proved to be a powerful and independent prognostic factor and a potential therapeutic target for patients with iCCA. |
| format | Article |
| id | doaj-art-df590400ecd14d6687173cd98785661a |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-df590400ecd14d6687173cd98785661a2025-02-03T01:23:44ZengWileyGastroenterology Research and Practice1687-61211687-630X2018-01-01201810.1155/2018/43692534369253SHMT2 Overexpression Predicts Poor Prognosis in Intrahepatic CholangiocarcinomaShanglei Ning0Siquan Ma1Abdul Qahar Saleh2Lingyu Guo3Zixiao Zhao4Yuxin Chen5Department of General Surgery, Qilu Hospital, Shandong University, Jinan, ChinaDepartment of General Surgery, Heze Second People’s Hospital, Heze, ChinaDepartment of General Surgery, Qilu Hospital, Shandong University, Jinan, ChinaDepartment of General Surgery, Qilu Hospital, Shandong University, Jinan, ChinaDepartment of General Surgery, Qilu Hospital, Shandong University, Jinan, ChinaDepartment of General Surgery, Qilu Hospital, Shandong University, Jinan, ChinaBackground and Objective. Serine hydroxymethyltransferase 2 (SHMT2) functions as a key enzyme in serine/glycine biosynthesis and one-carbon metabolism. Recent studies have shown that SHMT2 participated in tumor growth and progression in a variety of cancer types. The objective of the present study is to explore the expression of SHMT2 and evaluate its prognostic value in patients with intrahepatic cholangiocarcinoma (iCCA). Patients and Methods. We retrospectively investigated the expression of SHMT2 in 100 primary iCCA samples through immunohistochemical (IHC) staining on a tissue array. Results. High SHMT2 expression was found in 52 of the 100 specimens. The results indicated that SHMT2 level was upregulated compared to adjacent nontumor intrahepatic bile duct tissue. Furthermore, SHMT2 level was closely associated with tumor T stage (P=0.017) and tumor TNM stage (P=0.041) in patients with iCCA, but not with age, gender, tumor size, tumor number, pathological grade, vascular invasion, or N stage. Moreover, Kaplan-Meier analysis suggested that patients with lower SHMT2 level have longer survival rate than those with high expression (45.8 vs 23.1%, P=0.030). Additionally, the multivariate analysis model indicated SHMT2 is an independent adverse prognosticator in iCCA. Conclusion. High SHMT2 level was correlated with poorer overall survival in patients with iCCA. SHMT2 was proved to be a powerful and independent prognostic factor and a potential therapeutic target for patients with iCCA.http://dx.doi.org/10.1155/2018/4369253 |
| spellingShingle | Shanglei Ning Siquan Ma Abdul Qahar Saleh Lingyu Guo Zixiao Zhao Yuxin Chen SHMT2 Overexpression Predicts Poor Prognosis in Intrahepatic Cholangiocarcinoma Gastroenterology Research and Practice |
| title | SHMT2 Overexpression Predicts Poor Prognosis in Intrahepatic Cholangiocarcinoma |
| title_full | SHMT2 Overexpression Predicts Poor Prognosis in Intrahepatic Cholangiocarcinoma |
| title_fullStr | SHMT2 Overexpression Predicts Poor Prognosis in Intrahepatic Cholangiocarcinoma |
| title_full_unstemmed | SHMT2 Overexpression Predicts Poor Prognosis in Intrahepatic Cholangiocarcinoma |
| title_short | SHMT2 Overexpression Predicts Poor Prognosis in Intrahepatic Cholangiocarcinoma |
| title_sort | shmt2 overexpression predicts poor prognosis in intrahepatic cholangiocarcinoma |
| url | http://dx.doi.org/10.1155/2018/4369253 |
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